Trial reportDigestive diseases and sciences2014
Depth of injury caused by liquid nitrogen cryospray: study of human patients undergoing planned esophagectomy.
Trial report in Digestive diseases and sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00754468 (A STUDY OF CRYOSPRAY ABLATIONTM USING SURGICAL RESECTION SPECIMENS TO DETERMINE TREATMENT EFFECT, DEPTH OF INJURY, AND SIDE EFFECTS IN THE ESOPHAGUS), which is not on this map. Cited by 11 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A STUDY OF CRYOSPRAY ABLATIONTM USING SURGICAL RESECTION SPECIMENS TO DETERMINE TREATMENT EFFECT, DEPTH OF INJURY, AND SIDE EFFECTS IN THE ESOPHAGUS (CSA Depth 3)
Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Spray Cryotherapy Esophageal Consortium Consensus Recommendations for Liquid Nitrogen Spray Cryotherapy in Barrett's Esophagus and Esophageal Cancer Using a Modified Delphi Process.The American journal of gastroenterology · 2026Article
- Freeze the Disease: Advances the Therapy for Barrett's Esophagus and Esophageal Adenocarcinoma.Cancers · 2025Review
- Improving clinical outcomes of Barrett's esophagus with high dose proton pump inhibitors and cryoablation.Annals of medicine · 2023Article
- Neoadjuvant cryotherapy improves dysphagia and may impact remission rates in advanced esophageal cancer.Endoscopy international open · 2019Article
- Cryotherapy in the management of premalignant and malignant conditions of the esophagus.World journal of gastroenterology · 2018Review
- Mucosal Ablation in Patients with Barrett's Esophagus: Fry or Freeze?Digestive diseases and sciences · 2018Review
- Efficacy and safety of liquid nitrogen cryotherapy for treatment of Barrett's esophagus.World journal of gastrointestinal endoscopy · 2017Article
- Cryoablation of a duodenal adenoma with intramucosal carcinoma.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2017Article
- Cryotherapy in gastrointestinal endoscopy.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2017Article
- Endoscopic applications of cryospray ablation therapy-from Barrett's esophagus and beyond.World journal of gastrointestinal endoscopy · 2016Review
- Endoscopic Cryotherapy for Barrett Esophagus.Gastroenterology & hepatology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCryotherapy using liquid nitrogen delivered endoscopically has been used for mucosal ablation of esophageal neoplasia. There are no data for the human esophagus on the depth of injury and effects of this technique.
aimProspective study to examine the effect of treatment and depth of injury to the human esophagus of liquid nitrogen spray cryotherapy for subjects with esophageal neoplasia before planned esophagectomy.
methodsLiquid nitrogen spray cryoablation was performed seven days before scheduled esophagectomy for seven males with esophageal carcinoma. Subjects were assigned to either treatment of four cycles of 10 s each (group 1) or two cycles of 20 s each (group 2) applied to a 2-cm segment of healthy esophagus above the tumor area. Main outcomes measured were: mean depth of injury (mm); surface displaying mucosal ablation, and adverse events.
resultsMucosal destruction was similar for both groups (group 1, 95%; group 2, 93%; p = NS). Deeper injury was observed for group 2; mean depth was 5.4 mm compared with 4.0 mm for group 1. Cryonecrosis reached the submucosa for 60% (12/20) of subjects in group 1 versus 93% (14/15) of subjects in group 2 (p = 0.04, two-tailed Fisher's exact test). No serious adverse events occurred. No perforation was seen in the resected esophagus.
conclusionMucosal ablation with liquid nitrogen spray cryotherapy was highly effective in inducing mucosal necrosis; the doses assessed had similar effects. Ablation reached the submucosa more often with longer spray time despite fewer treatment cycles.
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