ArticleJournal of muscle research and cell motility1987
The extent of amino-terminal heterogeneity in rabbit fast skeletal muscle troponin T.
Article in Journal of muscle research and cell motility, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 58 citations in OpenAlex.
- Complex tropomyosin and troponin T isoform expression patterns in orbital and global fibers of adult dog and rat extraocular muscles.Journal of muscle research and cell motility · 2013Article
- Troponin T isoform expression is modulated during Atlantic halibut metamorphosis.BMC developmental biology · 2007Article
- Myofibrillar troponin exists in three states and there is signal transduction along skeletal myofibrillar thin filaments.Journal of molecular biology · 2006Article
- Development and composition of skeletal muscle fibres in mouse oesophagus.Journal of muscle research and cell motility · 2000Article
- Characterisation of troponin-T from salmonid fish.Journal of muscle research and cell motility · 1999Article
- Calcium ion regulation of muscle contraction: the regulatory role of troponin T.Molecular and cellular biochemistry · 1999Review
- Stretch activation and isoforms of myosin heavy chain and troponin-T of rat skeletal muscle fibres.Journal of muscle research and cell motility · 1997Article
- Human and murine dystrophin mRNA transcripts are differentially expressed during skeletal muscle, heart, and brain development.Nucleic acids research · 1992Article
- Variations in contractile properties of rabbit single muscle fibres in relation to troponin T isoforms and myosin light chains.The Journal of physiology · 1988Article
- Identification and distribution of the fast class of troponin T in the adult and developing avian skeletal muscle.Journal of muscle research and cell motility · 1988Article
- Expression of a novel combination of fast and slow troponin T isoforms in rabbit extraocular muscles.Journal of muscle research and cell motility · 1988Article
- The extent of amino-terminal heterogeneity in rabbit fast skeletal muscle troponin T.Journal of muscle research and cell motility · 1987Article
- Patterns of troponin T expression in mammalian fast, slow and promiscuous muscle fibres.Journal of muscle research and cell motility · 1987Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The extent and nature of fast troponin T (TnT) heterogeneity has been assessed in rabbit skeletal muscle. Previous studies identified two major fast TnT species (TnT1f and TnT2f), in the fast white muscle erector spinae, differing in their N-terminal cyanogen bromide (CNBr) fragments. Here a monoclonal antibody that recognizes a conserved region of TnT was used to characterize two additional TnT species (TnT3f and TnT4f) in the epaxial and limb musculature and a minor species (TnTcf) in craniofacial muscles. A combination of CNBr peptide mapping, immunoblotting and specific labelling of the N-terminus shows that these TnT species also differ in their N-terminal region. This observation is consistent with cDNA studies that predicted the N-terminal region is hypervariable. One additional species, a variant of TnT2f present in the tongue, was identified by two-dimensional gel electrophoresis. The limited number of TnT variants indicates that the full potential for heterogeneity inferred from the cDNA studies is not realized. This conclusion is supported by immunoblot analysis with a monoclonal antibody that recognizes an epitope in the hypervariable N-terminal region which is present in all variants of TnT1f and TnT2f but absent from the lower molecular weight species TnT3f and TnT4f.
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