ArticleJournal of clinical laboratory analysis2014
Ischemia-modified albumin may be a novel marker for the diagnosis and follow-up of necrotizing enterocolitis.
Article in Journal of clinical laboratory analysis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 38 citations in OpenAlex.
- The Potential Value of Mean Platelet Volume and Platelet Distribution Width as Inflammatory Indicators in Surgical Necrotizing Enterocolitis.Journal of inflammation research · 2024Article
- Recent Potential Noninvasive Biomarkers in Necrotizing Enterocolitis.Gastroenterology research and practice · 2019Review
- Is neutrophil gelatinase-associated lipocalin a good diagnostic marker for renal injury in asphyxiated preterm infants?Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2018Article
- Relationship Between Hemodynamically Significant Ductus Arteriosus and Ischemia-Modified Albumin in Premature Infants.Indian journal of clinical biochemistry : IJCB · 2016Article
- Serum Ischemia-Modified Albumin in Preterm Babies with Respiratory Distress Syndrome.Indian journal of clinical biochemistry : IJCB · 2016Article
- Neonatal physiological correlates of near-term brain development on MRI and DTI in very-low-birth-weight preterm infants.NeuroImage. Clinical · 2014Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimWe investigate the efficacy of serial ischemia-modified albumin (IMA) measurements in diagnosis and follow-up of necrotizing enterocolitis (NEC), and compare its effectiveness with C-reactive protein (CRP), interleukin-6 (IL-6), in NEC.
methodsPreterm infants, whose gestational age and weight matched each other, were grouped as control (n = 36) and NEC (n = 37). IMA, CRP, IL-6 levels were measured on the third day of life for the control group and on the day of diagnosis (first day), third, and seventh days of NEC.
resultsIMA, CRP, and IL-6 levels were significantly increased in NEC patients compared to the control group (P < 0.001) on the follow-up. IMA levels were significantly higher in infants with stage-III NEC than those in infants with stage-II NEC on the first, third, and seventh days (P < 0.001). The area under curve for IMA (0.815 at diagnosis, 0.933 at the third day, 0.935 at the seventh day) were significantly higher than CRP and IL-6 at all days for predicting perforation in infants with NEC (P < 0.001). Similarly, the area under curve for IMA (0.952 at diagnosis, 0.929 at the third day, 0.971 at the seventh day) was significantly higher than CRP and IL-6 at all consequent days of diagnosis for predicting mortality in infants with NEC (P < 0.001).
conclusionIschemia-modified albumin was found to be superior to CRP and IL-6 in both diagnosis and follow-up of NEC.
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