ArticleJournal of molecular neuroscience : MN2014
Higher circulating levels of chemokine CCL20 in patients with multiple sclerosis: evaluation of the influences of chemokine gene polymorphism, gender, treatment and disease pattern.
Article in Journal of molecular neuroscience : MN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- The Effects of IFN-β 1a on the Expression of Inflammasomes and Apoptosis-Associated Speck-Like Proteins in Multiple Sclerosis Patients.Molecular neurobiology · 2017Trial
- Elevated CCL20 expression was associated with poor prognosis for breast cancer.Journal of the Chinese Medical Association : JCMA · 2025Article
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- Article
- The Relationship Between Chemokine and Chemokine Receptor Genes Polymorphisms and Chronic Obstructive Pulmonary Disease Susceptibility in Tatar Population from Russia: A Case Control Study.Biochemical genetics · 2022Article
- Long-Term Effects of Alemtuzumab on CD4+ Lymphocytes in Multiple Sclerosis Patients: A 72-Month Follow-Up.Frontiers in immunology · 2022Article
- Potential Role of Ginger (Frontiers in nutrition · 2022Review
- RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis.Cell reports · 2021Article
- A comprehensive review on the role of chemokines in the pathogenesis of multiple sclerosis.Metabolic brain disease · 2021Review
- Pleural cytokines MIF and MIP-3α as novel biomarkers for complicated parapneumonic effusions and empyema.Scientific reports · 2021Article
- The role of chemokines and chemokine receptors in multiple sclerosis.International immunopharmacology · 2020Review
- Genetic polymorphism patterns suggest a genetic driven inflammatory response as pathogenesis in appendicitis.International journal of colorectal disease · 2020Article
- Targeting Chemokines and Chemokine Receptors in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.Journal of inflammation research · 2020Review
- Ectopic Lymphoid Follicles in Multiple Sclerosis: Centers for Disease Control?Frontiers in neurology · 2020Review
- Genetic and Molecular Biology of Multiple Sclerosis Among Iranian Patients: An Overview.Cellular and molecular neurobiology · 2020Review
- The Modulatory Effects of Vitamin D on the Expression of IL-12 and TGF-β in the Spinal Cord and Serum of Mice with Experimental Autoimmune Encephalomyelitis.Iranian journal of pathology · 2018Article
- Circulating concentrations of interleukin (IL)-17 in patients with multiple sclerosis: Evaluation of the effects of gender, treatment, disease patterns and IL-23 receptor gene polymorphisms.Iranian journal of neurology · 2017Article
- Altered Expression of Specific Transcription Factors of Th17 (RORγt, RORα) and Treg Lymphocytes (FOXP3) by Peripheral Blood Mononuclear Cells from Patients with Multiple Sclerosis.Journal of molecular neuroscience : MN · 2016Article
- Alemtuzumab long-term immunologic effect: Treg suppressor function increases up to 24 months.Neurology(R) neuroimmunology & neuroinflammation · 2016Article
- The dynamics of mucosal-associated invariant T cells in multiple sclerosis.SpringerPlus · 2016Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemokines play an important role in the autoimmune diseases. The aim of this study was to investigate the levels of CCL20 and a polymorphism [-786C > T (rs6749704)] in the chemokine gene in patients with multiple sclerosis (MS). The blood samples were collected from 135 MS patients and 135 healthy subjects as a control group. The patients have relapsing-remitting (RRMS; n = 65), primary progressive (PPMS; n = 47), secondary progressive (SPMS; n = 35) or progressive relapsing (PRMS; n = 14) patterns. The serum levels of CCL20 were measured by ELISA. The DNA was analyzed for CCL20 polymorphism using PCR-RLFP. The mean serum levels of CCL20 in the MS group were significantly higher than in the healthy group (P < 0.001). In patients with a SPMS pattern, the frequency of CT genotype at rs6749704 (24.3 %) was significantly lower as compared to patients with other patterns (42.8 %; P < 0.04). No significant differences were observed between subjects with different genotypes in rs6749704 regarding the CCL20 levels. The mean serum levels of CCL20 in both newly diagnosed and previously diagnosed patients was significantly higher than in the healthy group (P < 0.05 and 0.001, respectively). The mean serum levels of CCL20 in patients with RRMS, SPMS and PPMS patterns were significantly higher than in the healthy group (P < 0.004, P < 0.04, and 0.05, respectively). The levels of CCL20 in untreated patients and in patients who received interferon-β, methylprednisolone or the combination of interferon-β plus methylprednisolone were higher as compared to the control group (P < 0.05, P < 0.03, P < 0.005, and P < 0.05, respectively). These results showed higher levels of CCL20 in patients that represent that the chemokine may play an important role in the pathogenesis of MS. The rs6749704 polymorphism was an associated SPMS pattern. The levels of CCL20 were not influenced by gender, disease pattern and treatment.
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