ArticleJournal of the American Society for Mass Spectrometry2014
Thermal proton transfer reactions in ultraviolet matrix-assisted laser desorption/ionization.
Article in Journal of the American Society for Mass Spectrometry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Beyond the Fixed Charge: A New On-Tissue Derivatisation Strategy Employing Photoionisable Chromophores for Mass Spectrometry Imaging of Amino-Containing Metabolites.Angewandte Chemie (International ed. in English) · 2026Article
- MALDI Matrix: Origins, Innovations, and Frontiers.Chemical reviews · 2026Review
- Single-Cell 5 μm-Resolution Dual-Polarity MALDI-MS Imaging without Matrix Reapplication.Analytical chemistry · 2025Article
- Single Cell mass spectrometry: Towards quantification of small molecules in individual cells.Trends in analytical chemistry : TRAC · 2024Article
- Desorption and ablation regimes in UV-MALDI: the critical fluence.RSC advances · 2022Article
- Molecular Networking and On-Tissue Chemical Derivatization for Enhanced Identification and Visualization of Steroid Glycosides by MALDI Mass Spectrometry Imaging.Analytical chemistry · 2022Article
- Spatial distribution of isobaric androgens in target tissues using chemical derivatization and MALDI-2 on a trapped ion mobility quadrupole time-of-flight instrument.RSC advances · 2021Article
- Validation of MALDI-MS imaging data of selected membrane lipids in murine brain with and without laser postionization by quantitative nano-HPLC-MS using laser microdissection.Analytical and bioanalytical chemistry · 2020Article
- Nanoparticle-based surface assisted laser desorption ionization mass spectrometry: a review.Mikrochimica acta · 2019Article
- Transmission-mode MALDI-2 mass spectrometry imaging of cells and tissues at subcellular resolution.Nature methods · 2019Article
- The Influence of MS Imaging Parameters on UV-MALDI Desorption and Ion Yield.Journal of the American Society for Mass Spectrometry · 2019Article
- Ionic Liquid-Assisted Laser Desorption/Ionization-Mass Spectrometry: Matrices, Microextraction, and Separation.Methods and protocols · 2018Review
- New insights into mechanisms of material ejection in MALDI mass spectrometry for a wide range of spot sizes.Scientific reports · 2018Article
- Matrix Optical Absorption in UV-MALDI MS.Journal of the American Society for Mass Spectrometry · 2018Article
- Generation and Propagation of MALDI Ion Packets Probed by Sheet-Like Nanosecond UV Laser Light.Mass spectrometry (Tokyo, Japan) · 2018Article
- Laser Pulse Width Dependence and Ionization Mechanism of Matrix-Assisted Laser Desorption/Ionization.Journal of the American Society for Mass Spectrometry · 2017Article
- Observing Proton Transfer Reactions Inside the MALDI Plume: Experimental and Theoretical Insight into MALDI Gas-Phase Reactions.Journal of the American Society for Mass Spectrometry · 2017Article
- Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry: Mechanistic Studies and Methods for Improving the Structural Identification of Carbohydrates.Mass spectrometry (Tokyo, Japan) · 2017Article
- Mechanism for odd-electron anion generation of dihydroxybenzoic acid isomers in matrix-assisted laser desorption/ionization mass spectrometry with density functional theory calculations.Rapid communications in mass spectrometry : RCM · 2016Article
- Critical factors determining the quantification capability of matrix-assisted laser desorption/ionization- time-of-flight mass spectrometry.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the reasons that thermally induced reactions are not considered a crucial mechanism in ultraviolet matrix-assisted laser desorption ionization (UV-MALDI) is the low ion-to-neutral ratios. Large ion-to-neutral ratios (10(-4)) have been used to justify the unimportance of thermally induced reactions in UV-MALDI. Recent experimental measurements have shown that the upper limit of the total ion-to-neutral ratio is approximately 10(-7) at a high laser fluence and less than 10(-7) at a low laser fluence. Therefore, reexamining the possible contributions of thermally induced reactions in MALDI may be worthwhile. In this study, the concept of polar fluid was employed to explain the generation of primary ions in MALDI. A simple model, namely thermal proton transfer, was used to estimate the ion-to-neutral ratios in MALDI. We demonstrated that the theoretical calculations of ion-to-neutral ratios exhibit the same trend and similar orders of magnitude compared with those of experimental measurements. Although thermal proton transfer may not generate all of the ions observed in MALDI, the calculations demonstrated that thermally induced reactions play a crucial role in UV-MALDI.
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