ArticleAnnals of biomedical engineering2014
Experimental and computational approach investigating burst fracture augmentation using PMMA and calcium phosphate cements.
Article in Annals of biomedical engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The healing process of vertebral body fracture in Wistar rats: creation of an animal model and demonstration of the impact of anterolateral vascularization disruption on bone healing.Journal of spine surgery (Hong Kong) · 2025Article
- Experimental and Computational Comparison of Intervertebral Disc Bulge for Specimen-Specific Model Evaluation Based on Imaging.Frontiers in bioengineering and biotechnology · 2021Article
- A Novel Modelling Methodology Which Predicts the Structural Behaviour of Vertebral Bodies under Axial Impact Loading: A Finite Element and DIC Study.Materials (Basel, Switzerland) · 2020Article
- Optimizing computational methods of modeling vertebroplasty in experimentally augmented human lumbar vertebrae.JOR spine · 2020Article
- Optimizing bone cement stiffness for vertebroplasty through biomechanical effects analysis based on patient-specific three-dimensional finite element modeling.Medical & biological engineering & computing · 2018Article
- Examination of an in vitro methodology to evaluate the biomechanical performance of nucleus augmentation in axial compression.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2018Article
- Methodology to Produce Specimen-Specific Models of Vertebrae: Application to Different Species.Annals of biomedical engineering · 2017Article
- Computational modelling of bone augmentation in the spine.Journal of orthopaedic translation · 2015Review
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Authors and funding
7 authors.
Funding
Abstract
The aim of the study was to use a computational and experimental approach to evaluate, compare and predict the ability of calcium phosphate (CaP) and poly (methyl methacrylate) (PMMA) augmentation cements to restore mechanical stability to traumatically fractured vertebrae, following a vertebroplasty procedure. Traumatic fractures (n = 17) were generated in a series of porcine vertebrae using a drop-weight method. The fractured vertebrae were imaged using μCT and tested under axial compression. Twelve of the fractured vertebrae were randomly selected to undergo a vertebroplasty procedure using either a PMMA (n = 6) or a CaP cement variation (n = 6). The specimens were imaged using μCT and re-tested. Finite element models of the fractured and augmented vertebrae were generated from the μCT data and used to compare the effect of fracture void fill with augmented specimen stiffness. Significant increases (p < 0.05) in failure load were found for both of the augmented specimen groups compared to the fractured group. The experimental and computational results indicated that neither the CaP cement nor PMMA cement could completely restore the vertebral mechanical behavior to the intact level. The effectiveness of the procedure appeared to be more influenced by the volume of fracture filled rather than by the mechanical properties of the cement itself.
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Registered trials
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