ArticleBMJ open2014
Maternal and perinatal risk factors for childhood cancer: record linkage study.
Article in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Risk factors for childhood brain tumours: A systematic review and meta-analysis of observational studies from 1976 to 2022.Cancer epidemiology · 2024Pooled it
- Hypertensive disorders of pregnancy and cancer risk in offspring: A systematic review and meta-analysis.iScience · 2026Article
- Article
- Maternal illnesses during pregnancy and the risk of childhood cancer: A medical-record based analysis (UKCCS).International journal of cancer · 2025Article
- Preeclampsia, antihypertensive medication use in pregnancy and risk of childhood cancer in offspring.Cancer causes & control : CCC · 2024Article
- Risk factors for tumors or leukemia development in the first two years of life.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2023Article
- Increased incidence of childhood lymphoma in children with a history of small for gestational age at birth.Archives of gynecology and obstetrics · 2022Article
- Mapping evidence on the risk factors associated with pediatric cancers in sub-Saharan Africa: a scoping review.Systematic reviews · 2022Article
- Machine Learning-Based DNA Methylation Score for Fetal Exposure to Maternal Smoking: Development and Validation in Samples Collected from Adolescents and Adults.Environmental health perspectives · 2020Article
- Maternal Smoking During Pregnancy Induces Persistent Epigenetic Changes Into Adolescence, Independent of Postnatal Smoke Exposure and Is Associated With Cardiometabolic Risk.Frontiers in genetics · 2019Article
- Pregnancy-associated cancers and birth outcomes in children: a Danish and Swedish population-based register study.BMJ open · 2018Article
- Maternal Immunization: New Perspectives on Its Application Against Non-Infectious Related Diseases in Newborns.Vaccines · 2017Review
- Parental age and childhood cancer risk: A Danish population-based registry study.Cancer epidemiology · 2017Article
- Prenatal exposure to tobacco smoke leads to increased mitochondrial DNA content in umbilical cord serum associated to reduced gestational age.International journal of environmental health research · 2017Article
- Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero.BMC genomics · 2016Article
- Cancer risks for relatives of children with cancer.Journal of cancer epidemiology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate maternal and perinatal risk factors for childhood cancer. STUDY
designCase-control analysis of linked records from the Aberdeen Maternity and Neonatal Databank with the Scottish Cancer Registry and the General Registry of Births and Deaths in Scotland was carried out.
settingAberdeen, Scotland.
participantsCases (n=176) comprised children diagnosed with cancer under 15 years or recorded as having died of cancer. Four controls per case were matched by age and gender. RISK FACTORS TESTED: Maternal age, body mass index, social class, marital status and smoking as well as pre-eclampsia, antepartum haemorrhage and previous miscarriage, gestational age, birth weight and Apgar scores were compared between groups to test for association with cancer. ORs with 95% CIs were calculated using conditional logistic regression in univariable and multivariable models.
resultsOf the maternal characteristics tested, mother's age at delivery (cases mean 28.9 (SD 5.6) years vs controls mean 30.2 (SD 4.6), p=0.002) and smoking status (38.6% smokers among cases, 29.7% among controls, p=0.034) were found to be different between groups. Of the perinatal factors tested, low Apgar score at 5 min (adjusted OR (AOR) 4.59, 95% CI 1.52 to 13.87) and delivery by caesarean section (AOR 1.95, 95% CI 1.30 to 2.92) showed statistically significant associations with childhood cancer in the multivariable model.
conclusionsYounger maternal age, maternal smoking, delivery by caesarean section and low Apgar score at 5 min were independently associated with increased risk of childhood cancer. These general findings should be interpreted with caution as this study did not have the power to detect any association with individual diagnostic categories of childhood cancer.
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