Evidence map›Paper›PMID 24394152›Full record

ReviewJournal of geriatric psychiatry and neurology2014

Positron emission tomography molecular imaging in late-life depression.

Kentaro Hirao, Gwenn S Smith

Open access · greenAbstract readReview
In one paragraph

Review in Journal of geriatric psychiatry and neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Kentaro HiraoDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Gwenn S Smith
Johns Hopkins University · US

Funding

Geriatric Depression: PET Studies of Pathophysiology and Treatment ResponseR01MH086881 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SMITH, GWENN S · 2010 to 2013
$2.7M
Longitudinal imaging of neuropsychiatric symptoms in mild cognitive impairmentR01AG041633 · NIA · JOHNS HOPKINS UNIVERSITY · PI SMITH, GWENN S · 2011 to 2015
$2.6M
PET Studies of Serotonin and Amyloid in MCIR01AG038893 · NIA · JOHNS HOPKINS UNIVERSITY · PI SMITH, GWENN S · 2011 to 2014
$2.4M
Serotonin Modulation in Geriatric DepressionR01MH064823 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SMITH, GWENN S. · 2003 to 2006
$1.9M
MONOAMINERGIC FUNCTION IN GERIATRIC NEUROPSYCHIATRYK02MH001621 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SMITH, GWENN S · 1998 to 2008
$884k
NIA NIH HHS R01 AG038893NIA NIH HHS R01 AG041633NIMH NIH HHS K02 MH001621NIMH NIH HHS MH 64823NIMH NIH HHS R01 MH064823NIMH NIH HHS R01 MH086881
6 · The paper itself

Abstract

Molecular imaging represents a bridge between basic and clinical neuroscience observations and provides many opportunities for translation and identifying mechanisms that may inform prevention and intervention strategies in late-life depression (LLD). Substantial advances in instrumentation and radiotracer chemistry have resulted in improved sensitivity and spatial resolution and the ability to study in vivo an increasing number of neurotransmitters, neuromodulators, and, importantly, neuropathological processes. Molecular brain imaging studies in LLD will be reviewed, with a primary focus on positron emission tomography. Future directions for the field of molecular imaging in LLD will be discussed, including integrating molecular imaging with genetic, neuropsychiatric, and cognitive outcomes and multimodality neuroimaging.

Indexed as

AcetylcholineAge of OnsetBrainDepressionDopamineHumansMolecular ImagingNeuroimagingPositron-Emission TomographyReceptors, SerotoninAcetylcholineDopamineReceptors, Serotoninacetylcholinedepressiondopaminemolecular imagingpositron emission tomographyserotonin

Identifiers

PMID24394152
PMCPMC5646279
OpenAlexW2171643750

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.