Evidence map›Paper›PMID 24393770›Full record

ArticleApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine2014

Evaluation of unnatural cyclic amino acids as boron delivery agents for treatment of melanomas and gliomas.

Rolf F Barth, George W Kabalka, Weilian Yang, Tianyao Huo, Robin J Nakkula, Aarif L Shaikh, Syed A Haider, Subhash Chandra

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Synthesis of New Promising BNCT Agents Based on Conjugates ofInternational journal of molecular sciences · 2024
    Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Boron delivery agents for neutron capture therapy of cancer.Cancer communications (London, England) · 2018
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Rolf F BarthThe Ohio State University, Department of Pathology, 4132 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA. Electronic address: rolf.barth@osumc.edu.
George W KabalkaUniversity of Tennessee, Department of Chemistry, 611 Buehler Hall, Knoxville, TN 37996, USA.
Weilian YangThe Ohio State University, Department of Pathology, 4132 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA.
Tianyao HuoThe Ohio State University, Department of Pathology, 4132 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA.
Robin J NakkulaThe Ohio State University, Department of Pathology, 4132 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA.
Aarif L ShaikhUniversity of Tennessee, Department of Chemistry, 611 Buehler Hall, Knoxville, TN 37996, USA.
Syed A HaiderCornell University, Department of Biomedical Engineering, Ithaca, NY 14853, USA.
Subhash ChandraCornell University, Department of Biomedical Engineering, Ithaca, NY 14853, USA.
The Ohio State University · USCornell University · USUniversity of Tennessee at Knoxville · US

Funding

Subcellular/Cell Cycle Boron-Delivery Studies of Unnatural Amino Acids by SIMSR01CA129326 · NCI · CORNELL UNIVERSITY · PI BARTH, ROLF F, CHANDRA, SUBHASH · 2009 to 2011
$910k
NCI NIH HHS R01 CA129326NCI NIH HHS R01CA129326
6 · The paper itself

Abstract

Unnatural cyclic amino acids (UNAAs) are a new class of boron delivery agents that are in a pre-clinical stage of evaluation. In the present study, the biodistribution of racemic forms of the cis- and trans-isomers of the boronated UNAA 1-amino-3-boronocyclopentanecarboxylic acid (ABCPC) and 1-amino-3-boronocycloheptanecarboxylic acid (ABCHC) were evaluted in B16 melanoma bearing mice and this was compared to l-p-boronophenylalanine (BPA). Boron concentrations were determined by inductively coupled plasma-optical emission spectroscopy (ICP-OES) at 2.5h following intraperitoneal (i.p.) injection of the test agents at a concentration equivalent to 24mg/B/kg. While all compounds attained comparable tumor boron concentrations, the tumor/blood (T/Bl) boron concentration ratios were far superior for both cis-ABCPC and cis-ABCHC compared to BPA (T/Bl=16.4, and 15.1 vs. 5.4). Secondary ion mass spectrometry (SIMS) imaging revealed that the cis-ABCPC delivered boron to the nuclei, as well as the cytoplasm of B16 cells. Next, a biodistribution study of cis-ABCPC and BPA was carried out in F98 glioma bearing rats following i.p. administration. Both compounds attained comparable tumor boron concentrations but the tumor/brain (T/Br) boron ratio was superior for cis-ABCPC compared to BPA (6 vs. 3.3). Since UNAAs are water soluble and cannot be metabolized by tumor cells, they could be potentially more effective boron delivery agents than BPA. Our data suggest that further studies are warranted to evaluate these compounds prior to the initiation of clinical studies.

Indexed as

Amino Acids, CyclicAnimalsBoron CompoundsBoron Neutron Capture TherapyCell Line, TumorDrug CarriersFemaleGliomaMelanomaMetabolic Clearance RateMiceMice, Inbred C57BLOrgan SpecificityRatsRats, Inbred F344Tissue DistributionAmino Acids, CyclicBoron CompoundsDrug CarriersGliomasMelanomasUnnatural cyclic amino acids

Identifiers

PMID24393770
PMCPMC4049841
OpenAlexW2016386037

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.