ReviewJournal of dental research2014
Immune cells link obesity-associated type 2 diabetes and periodontitis.
Review in Journal of dental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 57 citations in OpenAlex.
- Periodontitis Induces B Cell-Macrophage Crosstalk to Exacerbate Glucose Dysregulation in Obesity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Impaired Mitophagy-Induced Apoptosis of Gingival Fibroblasts Exacerbates Diabetic Periodontitis Via THBS-1/CD36-Dependent Macrophage Activation.Inflammation · 2026Article
- Diabesity and Oral Immunity: Exploring the Interconnection.Advances in experimental medicine and biology · 2026Review
- An explorative study on the interaction of cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1/ANRIL) gene polymorphism with obesity on periodontitis among Norwegian adults.Acta odontologica Scandinavica · 2025Article
- Interaction of the Systemic Inflammatory State, Inflammatory Mediators, and the Oral Microbiome.Advances in experimental medicine and biology · 2025Review
- Impact of periodontitis on type 2 diabetes: a bioinformatic analysis.BMC oral health · 2024Article
- Obesity and periodontitis: a comprehensive review of their interconnected pathophysiology and clinical implications.Frontiers in nutrition · 2024Review
- T cells dominate peripheral inflammation in a cross-sectional analysis of obesity-associated diabetes.Obesity (Silver Spring, Md.) · 2022Article
- Novel Preosteoclast Populations in Obesity-Associated Periodontal Disease.Journal of dental research · 2022Article
- Pyroptosis in periodontitis: From the intricate interaction with apoptosis, NETosis, and necroptosis to the therapeutic prospects.Frontiers in cellular and infection microbiology · 2022Review
- Human periodontitis-associated salivary microbiome affects the immune response of diabetic mice.Journal of oral microbiology · 2022Article
- Screening of crosstalk and pyroptosis-related genes linking periodontitis and osteoporosis based on bioinformatics and machine learning.Frontiers in immunology · 2022Article
- The bidirectional biological interplay between microbiome and viruses in periodontitis and type-2 diabetes mellitus.Frontiers in immunology · 2022Review
- Myeloid-derived suppressor cells in obesity-associated periodontal disease: A conceptual model.Periodontology 2000 · 2021Review
- MPI-based bioinformatic analysis and co-inhibitory therapy with mannose for oral squamous cell carcinoma.Medical oncology (Northwood, London, England) · 2021Article
- Porphyromonas gingivalis exacerbates the progression of fatty liver disease via CD36-PPARγ pathway.BMB reports · 2021Article
- Accuracy of a 7-Item Patient-Reported Stand-Alone Tool for Periodontitis Screening.Journal of clinical medicine · 2021Article
- Single-Cell Analysis of the Periodontal Immune Niche in Type 2 Diabetes.Journal of dental research · 2020Article
- Gingimaps: Protein Localization in the Oral PathogenMicrobiology and molecular biology reviews : MMBR · 2020Review
- Aberrant Periodontal and Systemic Immune Response of Overweight Rodents to Periodontal Infection.BioMed research international · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The clinical association between obesity-associated type 2 diabetes (T2D) and periodontitis, coupled with the increasing prevalence of these diseases, justifies studies to identify mechanisms responsible for the vicious feed-forward loop between systemic and oral disease. Changes in the immune system are critical for both obesity-associated T2D and periodontitis and therefore may link these diseases. Recent studies at the intersection of immunology and metabolism have greatly advanced our understanding of the role the immune system plays in the transition between obesity and obesity-associated T2D and have shown that immune cells exhibit similar functional changes in obesity/T2D and periodontitis. Furthermore, myeloid and lymphoid cells likely synergize to promote obesity/T2D-associated periodontitis despite complexities introduced by disease interaction. Thus the groundwork is being laid for researchers to exploit existing models to understand immune cell dysfunction and break the devastating relationship between obesity-associated T2D and oral disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.