ArticleThe Journal of infection2014
Dynamics of acquisition and loss of carriage of Staphylococcus aureus strains in the community: the effect of clonal complex.
Article in The Journal of infection, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Nasal microbiome inhabitants with anti-Microbiology spectrum · 2025Article
- Different evolution ofHeliyon · 2024Article
- Article
- Colonization and transmission ofMicrobial genomics · 2023Article
- Nasal microbiome disruption and recovery after mupirocin treatment in Staphylococcus aureus carriers and noncarriers.Scientific reports · 2022Article
- Antimicrobial resistance determinants are associated withMicrobial genomics · 2021Article
- Article
- Nasal Methicillin-ResistantOpen forum infectious diseases · 2021Article
- A Bayesian model of acquisition and clearance of bacterial colonization incorporating within-host variation.PLoS computational biology · 2019Article
- Article
- Novel Methicillin-ResistantFrontiers in microbiology · 2019Article
- Longitudinal Population Dynamics ofFrontiers in genetics · 2019Article
- Cost-effectiveness of pre-operative Staphylococcus aureus screening and decolonization.Infection control and hospital epidemiology · 2018Article
- Cessation from Smoking Improves Innate Host Defense and Clearance of Experimentally Inoculated Nasal Staphylococcus aureus.Infection and immunity · 2018Article
- Decolonization ofJournal of healthcare engineering · 2018Review
- Development of persistent gastrointestinal S. aureus carriage in mice.Scientific reports · 2017Article
- Whole-Genome Sequencing Reveals the Contribution of Long-Term Carriers in Staphylococcus aureus Outbreak Investigation.Journal of clinical microbiology · 2017Article
- Multi-site and nasal swabbing for carriage of Staphylococcus aureus: what does a single nose swab predict?The Journal of hospital infection · 2017Article
- Article
- Validation of self-administered nasal swabs and postage for the isolation of Staphylococcus aureus.Journal of medical microbiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundStaphylococcus aureus nasal carriage increases infection risk. However, few studies have investigated S. aureus acquisition/loss over >1 year, and fewer still used molecular typing.
methods1123 adults attending five Oxfordshire general practices had nasal swabs taken. 571 were re-swabbed after one month then every two months for median two years. All S. aureus isolates were spa-typed. Risk factors were collected from interviews and medical records.
results32% carried S. aureus at recruitment (<1% MRSA). Rates of spa-type acquisition were similar in participants S. aureus positive (1.4%/month) and negative (1.8%/month, P = 0.13) at recruitment. Rates were faster in those carrying clonal complex (CC)15 (adjusted (a)P = 0.03) or CC8 (including USA300) (aP = 0.001) at recruitment versus other CCs. 157/274 (57%) participants S. aureus positive at recruitment returning ≥ 12 swabs carried S. aureus consistently, of whom 135 carried the same spa-type. CC22 (including EMRSA-15) was more prevalent in long-term than intermittent spa-type carriers (aP = 0.03). Antibiotics transiently reduced carriage, but no other modifiable risk factors were found.
conclusionsBoth transient and longer-term carriage exist; however, the approximately constant rates of S. aureus gain and loss suggest that 'never' or truly 'persistent' carriage are rare. Long-term carriage varies by strain, offering new explanations for the success of certain S. aureus clones.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.