ArticleScandinavian journal of trauma, resuscitation and emergency medicine2014
Prehospital risk factors of mortality and impaired consciousness after severe traumatic brain injury: an epidemiological study.
Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Hypotension and Adverse Outcomes in Moderate to Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- The Impact of Accidental Hypothermia on Mortality in Trauma Patients Overall and Patients with Traumatic Brain Injury Specifically: A Systematic Review and Meta-Analysis.World journal of surgery · 2020Pooled it
- Preliminary Study of Vagus Nerve Magnetic Modulation in Patients with Prolonged Disorders of Consciousness.Neuropsychiatric disease and treatment · 2022Trial
- Prevalence of hypothermia prior to trauma center arrival and associated mortality in pediatric traumatic brain injury patients.Pediatric surgery international · 2026Article
- Impact of Initial Care at a Neurosurgery-Capable Facility on Mortality Among Patients with Moderate-to-Severe Traumatic Brain Injury in South Africa.Neurocritical care · 2026Article
- Impact of Prehospital Blood Pressure Profile on Functional Outcome After Traumatic Brain Injury.Journal of clinical medicine · 2025Article
- Significance of a hypotensive episode following traumatic injury: A retrospective observational study.World journal of critical care medicine · 2025Article
- The incidence and outcomes of hyperacute cardiovascular dysfunction following isolated traumatic brain injury: an observational cohort study.International journal of surgery (London, England) · 2025Observational
- Adverse Prehospital Events and Outcomes After Traumatic Brain Injury.JAMA network open · 2025Article
- Article
- Provider Perceptions of Oxygenation Strategies for Critically Ill Trauma Patients With and Without Moderate-to-Severe Traumatic Brain Injury.Military medicine · 2023Article
- Long-Term Outcomes in Severe Traumatic Brain Injury and Associated Factors: A Prospective Cohort Study.Journal of clinical medicine · 2022Article
- Sex and age differences in isolated traumatic brain injury: a retrospective observational study.BMC neurology · 2021Observational
- Severe traumatic brain injury and hypotension is a frequent and lethal combination in multiple trauma patients in mountain areas - an analysis of the prospective international Alpine Trauma Registry.Scandinavian journal of trauma, resuscitation and emergency medicine · 2021Article
- Article
- Effect of Pre-Hospital Intubation in Patients with Severe Traumatic Brain Injury on Outcome: A Prospective Cohort Study.Journal of clinical medicine · 2019Article
- Accidental hypothermia as an independent risk factor of poor neurological outcome in older multiply injured patients with severe traumatic brain injury: a matched pair analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2019Article
- Prehospital and Emergency Care in Adult Patients with Acute Traumatic Brain Injury.Medical sciences (Basel, Switzerland) · 2019Review
- Integrated Health Care Management of Moderate to Severe TBI in Older Patients-A Narrative Review.Current neurology and neuroscience reports · 2017Review
- Association between the Osteoporosis Self-Assessment Tool for Asians Score and Mortality in Patients with Isolated Moderate and Severe Traumatic Brain Injury: A Propensity Score-Matched Analysis.International journal of environmental research and public health · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere traumatic brain injury (TBI) is a significant health concern and a major burden for society. The period between trauma event and hospital admission in an emergency department (ED) could be a determinant for secondary brain injury and early survival. The aim was to investigate the relationship between prehospital factors associated with secondary brain injury (arterial hypotension, hypoxemia, hypothermia) and the outcomes of mortality and impaired consciousness of survivors at 14 days.
methodsA multicenter, prospective cohort study was performed in dedicated trauma centres of Switzerland. Adults with severe TBI (Abbreviated Injury Scale score of head region (HAIS) >3) were included. Main outcome measures were death and impaired consciousness (Glasgow Coma Scale (GCS) ≤13) at 14 days. The associations between risk factors and outcome were assessed with univariate and multivariate regression models.
results589 patients were included, median age was 55 years (IQR 33, 70). The median GCS in ED was 4 (IQR 3-14), with abnormal pupil reaction in 167 patients (29.2%). Median ISS was 25 (IQR 21, 34). Three hundred seven patients sustained their TBI from falls (52.1%) and 190 from a road traffic accidents (32.3%). Median time from Out-of-hospital Emergency Medical Service (OHEMS) departure on scene to arrival in ED was 50 minutes (IQR 37-72); 451 patients had a direct admission (76.6%). Prehospital hypotension was observed in 24 (4.1%) patients, hypoxemia in 73 (12.6%) patients and hypothermia in 146 (24.8%). Prehospital hypotension and hypothermia (apart of age and trauma severity) was associated with mortality. Prehospital hypoxemia (apart of trauma severity) was associated with impaired consciousness; indirect admission was a protective factor.
conclusionMortality and impaired consciousness at 14 days do not have the same prehospital risk factors; prehospital hypotension and hypothermia is associated with mortality, and prehospital hypoxemia with impaired consciousness.
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