ArticleBMC cancer2014
High-resolution 3D micro-CT imaging of breast microcalcifications: a preliminary analysis.
Article in BMC cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Micro-CT radiomics reveals the microcalcification-surrounding tissue interface as the diagnostic epicenter of breast microcalcifications.Breast cancer research : BCR · 2026Article
- Rapid Arbitrary-Shape Microscopy of Unsectioned Tissues for Precise Intraoperative Tumor Margin Assessment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Diagnostic feasibility study of stereoscopic optical palpation for breast tumour margin assessment.BMC cancer · 2025Article
- High-resolution microCT to assess breast microcalcification morphometry by histologic lesion subtype and radiologic classification.Breast cancer research and treatment · 2025Article
- Mechanisms of osteopontin-stabilized amorphous calcium phosphate calcification in benign and pre-malignant breast disease.Scientific reports · 2025Article
- Real-time peri-operative microcalcification detection in superficial breast tissues.Scientific reports · 2025Article
- Micro-computed Tomography in the Evaluation of Eosin-stained Axillary Lymph Node Biopsies of Females Diagnosed with Breast Cancer.Scientific reports · 2024Article
- Micro-CT Microcalcification Analysis: A Scoping Review of Current Applications and Future Potential in Breast Cancer Research.Tomography (Ann Arbor, Mich.) · 2024Article
- Multifractal analysis of cellular ATR-FTIR spectrum as a method for identifying and quantifying cancer cell metastatic levels.Scientific reports · 2023Article
- The Value of Micro-CT in the Diagnosis of Lung Carcinoma: A Radio-Histopathological Perspective.Diagnostics (Basel, Switzerland) · 2023Review
- Improved automated early detection of breast cancer based on high resolution 3D micro-CT microcalcification images.BMC cancer · 2022Article
- High-resolutionJournal of medical imaging (Bellingham, Wash.) · 2021Article
- Emerging Technologies for Real-Time Intraoperative Margin Assessment in Future Breast-Conserving Surgery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Micro-computed tomography enables rapid surgical margin assessment during breast conserving surgery (BCS): correlation of whole BCS micro-CT readings to final histopathology.Breast cancer research and treatment · 2018Article
- Review of methods for intraoperative margin detection for breast conserving surgery.Journal of biomedical optics · 2018Review
- Review of quantitative multiscale imaging of breast cancer.Journal of medical imaging (Bellingham, Wash.) · 2018Review
- A Micro CT Study in Patients with Breast Microcalcifications Using a Mathematical Algorithm to Assess 3D Structure.PloS one · 2017Article
- Improved Diagnostics by Assessing the Micromorphology of Breast Calcifications via X-Ray Dark-Field Radiography.Scientific reports · 2016Article
- Investigation of spatial resolution characteristics of an in vivo micro computed tomography system.Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment · 2016Article
- The impact of spectral filtration on image quality in micro-CT system.Journal of applied clinical medical physics · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
backgroundDetection of microcalcifications on mammograms indicates the presence of breast lesion, and the shapes of the microcalcifications as seen by conventional mammography correlates with the probability of malignancy. This preliminary study evaluated the 3D shape of breast microcalcifications using micro-computed tomography (micro-CT) and compared the findings with those obtained using anatomopathological analysis.
methodsThe study analyzed breast biopsy samples from 11 women with findings of suspicious microcalcifications on routine mammograms. The samples were imaged using a micro-CT (SkyScan 1076) at a resolution of 35 μm. Images were reconstructed using filtered back-projection and analyzed in 3D using surface rendering. The samples were subsequently analyzed by the pathology service. Reconstructed 3D images were compared with the corresponding histological slices.
resultsAnatomopathological analysis showed that 5 of 11 patients had ductal breast carcinoma in situ. One patient was diagnosed with invasive ductal carcinoma.Individual object analysis was performed on 597 microcalcifications. Malignant microcalcifications tended to be thinner and to have a smaller volume and surface area, while their surface area-to-volume ratio was greater than that of benign microcalcifications. The structure model index values were the same for malignant and benign microcalcifications.
conclusionsThis is the first study to use micro-CT for quantitative 3D analysis of microcalcifications. This high-resolution imaging technique will be valuable for gaining a greater understanding of the morphologic characteristics of malignant and benign microcalcifications. The presence of many small microcalcifications can be an indication of malignancy. For the larger microcalcifications, 3D parameters confirmed the more irregular shape of malignant microcalcifications.
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