ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2014
Use of IgE and IgG4 epitope binding to predict the outcome of oral immunotherapy in cow's milk allergy.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 67 citations in OpenAlex.
- Predicting development of sustained unresponsiveness to milk oral immunotherapy using epitope-specific antibody binding profiles.The Journal of allergy and clinical immunology · 2019Trial
- Regulatory B cells contribute to allergen-encapsulating nanoparticle immunotherapy efficacy for food allergy.JCI insight · 2026Article
- Long-term efficacy and safety of cow's milk anaphylaxis specific immunotherapy: Allergen unresponsiveness via the Tolerance Induction Program.The journal of allergy and clinical immunology. Global · 2024Article
- Low-dose oral immunotherapy in immunoglobulin E-mediated food allergies.Frontiers in immunology · 2024Review
- Mechanisms of Allergen Immunotherapy and Potential Biomarkers for Clinical Evaluation.Journal of personalized medicine · 2023Review
- IgE and IgG4 Epitopes of Dermatophagoides and Blomia Allergens before and after Sublingual Immunotherapy.International journal of molecular sciences · 2023Article
- IgE and IgG4 Epitope Mapping of Food Allergens with a Peptide Microarray Immunoassay.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Biomarkers and mechanisms of tolerance induction in food allergic patients drive new therapeutic approaches.Frontiers in immunology · 2022Review
- Oral Immunotherapy in Food Allergy: A Critical Pediatric Perspective.Frontiers in pediatrics · 2022Review
- Oral Immunotherapy for Children with Cow's Milk Allergy.Pathogens (Basel, Switzerland) · 2021Review
- Digestomics of Cow's Milk: Short Digestion-Resistant Peptides of Casein Form Functional Complexes by Aggregation.Foods (Basel, Switzerland) · 2020Article
- Oral Immunotherapy for Cow’s Milk Allergy: Five Years’ Experience from a Single Center in TurkeyBalkan medical journal · 2020Article
- A WAO - ARIA - GAThe World Allergy Organization journal · 2020Article
- Novel Bead-Based Epitope Assay is a sensitive and reliable tool for profiling epitope-specific antibody repertoire in food allergy.Scientific reports · 2019Article
- Component-Resolved Diagnosis in Food Allergies.Medicina (Kaunas, Lithuania) · 2019Review
- Can alternative epitope mapping approaches increase the impact of B-cell epitopes in food allergy diagnostics?Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Review
- Cow's milk oral immunotherapy in real life: 8-year long-term follow-up study.Asia Pacific allergy · 2018Article
- Breast milk IgA to foods has different epitope specificity than serum IgA-Evidence for entero-mammary link for food-specific IgA?Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017Article
- Prevention and Management of Cow's Milk Allergy in Non-Exclusively Breastfed Infants.Nutrients · 2017Review
- Contribution of Molecular Allergen Analysis in Diagnosis of Milk Allergy.Current allergy and asthma reports · 2017Review
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundOral immunotherapy (OIT) with cow's milk (CM) has been reported to induce a number of specific antibody responses, but these remain to be fully characterized. Our objective was to explore whether IgE and IgG4 epitope binding profiles could predict the risk of side effects during CM OIT.
methodsThe study population consisted of 32 children (6-17 yr of age) with CM allergy: 26 children who successfully completed OIT and six children who discontinued therapy due to adverse reactions. We investigated sera drawn before and after OIT. We analyzed specific IgE and IgG4 binding to CM protein-derived peptides with a microarray-based immunoassay. Antibody binding affinity was analyzed with a competition assay where CM proteins in solution competed with peptides printed on the microarray.
resultsIgE binding to CM peptides decreased and IgG4 binding increased following the OIT in children who attained desensitization. Compared with children who successfully completed OIT, those who discontinued OIT due to adverse reactions developed increased quantities and affinity of epitope-specific IgE antibodies and a broader diversity of IgE and IgG4 binding, but less overlap in IgE and IgG4 binding to CM peptides.
conclusionsDetailed analysis of IgE and IgG4 binding to CM peptides may help in predicting whether CM OIT will be tolerated successfully. It may thus improve the safety of the therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.