ArticleJournal of neurotrauma2014
Diffusion tensor imaging reveals white matter injury in a rat model of repetitive blast-induced traumatic brain injury.
Article in Journal of neurotrauma, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Wartime blast induced mild traumatic brain injury in the military, damage to white matter tracts, and neuropsychological symptoms: a systematic review.Neurosurgical review · 2025Pooled it
- Diffusion Tensor Imaging-Based Studies at the Group-Level Applied to Animal Models of Neurodegenerative Diseases.Frontiers in neuroscience · 2020Pooled it
- Primary Blast-Induced Traumatic Brain Injury as a Risk Factor for (Cerebro)vascular Disorder: Clinical Manifestations, Blast Physics, Biomechanics, Pathobiology, and Critical Gaps.International journal of molecular sciences · 2026Review
- Tissue optimization strategies for high-quality ex vivo diffusion imaging.NMR in biomedicine · 2023Article
- Time Course of Remote Neuropathology Following Diffuse Traumatic Brain Injury in the Male Rat.Experimental neurobiology · 2022Article
- Repeated blast mild traumatic brain injury and oxycodone self-administration produce interactive effects on neuroimaging outcomes.Addiction biology · 2022Article
- Blast-induced axonal degeneration in the rat cerebellum in the absence of head movement.Scientific reports · 2022Article
- A multicontrast MR atlas of the Wistar rat brain.NeuroImage · 2021Article
- Investigation of the direct and indirect mechanisms of primary blast insult to the brain.Scientific reports · 2021Article
- Combined Diffusion Tensor Imaging and Quantitative Susceptibility Mapping Discern Discrete Facets of White Matter Pathology Post-injury in the Rodent Brain.Frontiers in neurology · 2020Article
- Blast Preconditioning Protects Retinal Ganglion Cells and Reveals Targets for Prevention of Neurodegeneration Following Blast-Mediated Traumatic Brian Injury.Investigative ophthalmology & visual science · 2019Article
- Small Animal Multivariate Brain Analysis (SAMBA) - a High Throughput Pipeline with a Validation Framework.Neuroinformatics · 2019Article
- A Comprehensive Review of Experimental Rodent Models of Repeated Blast TBI.Frontiers in neurology · 2019Review
- Diffusion MRI and the detection of alterations following traumatic brain injury.Journal of neuroscience research · 2018Review
- Repeated mild blast exposure in young adult rats results in dynamic and persistent microstructural changes in the brain.NeuroImage. Clinical · 2018Article
- A Comparative Study of Two Blast-Induced Traumatic Brain Injury Models: Changes in Monoamine and Galanin Systems Following Single and Repeated Exposure.Frontiers in neurology · 2018Article
- Modeling the Long-Term Consequences of Repeated Blast-Induced Mild Traumatic Brain Injuries.Journal of neurotrauma · 2017Article
- Uncovering the neuroanatomical correlates of cognitive, affective and conative theory of mind in paediatric traumatic brain injury: a neural systems perspective.Social cognitive and affective neuroscience · 2017Article
- Repetitive Closed-Head Impact Model of Engineered Rotational Acceleration Induces Long-Term Cognitive Impairments with Persistent Astrogliosis and Microgliosis in Mice.Journal of neurotrauma · 2017Article
- Combined Diffusion Tensor and Magnetic Resonance Spectroscopic Imaging Methodology for Automated Regional Brain Analysis: Application in a Normal Pediatric Population.Developmental neuroscience · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Blast-induced traumatic brain injury (bTBI) is one of the most common combat-related injuries seen in U.S. military personnel, yet relatively little is known about the underlying mechanisms of injury. In particular, the effects of the primary blast pressure wave are poorly understood. Animal models have proven invaluable for the study of primary bTBI, because it rarely occurs in isolation in human subjects. Even less is known about the effects of repeated primary blast wave exposure, but existing data suggest cumulative increases in brain damage with a second blast. MRI and, in particular, diffusion tensor imaging (DTI), have become important tools for assessing bTBI in both clinical and preclinical settings. Computational statistical methods such as voxelwise analysis have shown promise in localizing and quantifying bTBI throughout the brain. In this study, we use voxelwise analysis of DTI to quantify white matter injury in a rat model of repetitive primary blast exposure. Our results show a significant increase in microstructural damage with a second blast exposure, suggesting that primary bTBI may sensitize the brain to subsequent injury.
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