Evidence map›Paper›PMID 24392605›Full record

ArticleEthnicity & disease2013

Fasting plasma ghrelin levels are reduced, but not suppressed during OGTT in obese African American adolescents.

Maurice B Fluitt, Kanwal K Gambhir, Gail Nunlee-Bland, Wolali Odonkor

Abstract readComparative Study
PubMed Full text at PMC
In one paragraph

Article in Ethnicity & disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Maurice B FluittDepartment of Medicine, College of Medicine of Howard University, Washington, DC 20060, USA.
Kanwal K GambhirDepartment of Genetics and Human Genetics and Molecular Endocrinology Laboratory, Howard University, Washington, DC 20060, USA.
Gail Nunlee-BlandDiabetes Treatment Center, Department of Medicine, College of Medicine, Howard University Hospital, Washington, DC 20060, USA.
Wolali OdonkorDiabetes Treatment Center, Department of Medicine, College of Medicine, Howard University Hospital, Washington, DC 20060, USA.
Howard University · USHoward University Hospital · US

Funding

WirelessTechnology Assisted Weight Management in Pre-Diabetic Adolescents...P20MD000198 · NIMHD · HOWARD UNIVERSITY · PI JENKINS, RENEE R. · 2002 to 2016
$17.2M
JHU-UMD Diabetes Research CenterP30DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WONDISFORD, FREDRIC E. · 2013 to 2017
$9.7M
NIDDK NIH HHS P30 DK079637NIMHD NIH HHS 2P20MD30198-06NIMHD NIH HHS P20 MD000198
6 · The paper itself

Abstract

objectiveOur study aimed to evaluate total plasma ghrelin (TGh) concentration and its correlation with leptin and insulin in obese African American (AA) adolescents with a family history of type 2 diabetes. PARTICIPANTS AND

methodsInsulin, leptin, and TGh were measured for 15 non-obese controls in fasted state and 19 obese AA adolescents on samples collected during oral glucose tolerance test (OGTT) using radioimmunoassay kits. The hormonal concentrations were compared at fasting levels between obese and non-obese AA adolescents. Insulin, leptin, and TGh concentrations were also compared during OGTT in the obese group.

resultsFasting TGh was significantly lower in obese AA adolescents compared to non-obese controls, while fasting leptin and insulin were significantly higher in obese AA adolescents compared to non-obese controls. During OGTT, for the obese group, TGh increased significantly and plasma leptin decreased significantly. A significant negative correlation was found between TGh and leptin at 30 and 120 min, but at no other time points (0, 60, and 90 min). A significant positive correlation was found between TGh and insulin at 30 min during OGTT, but no other time points.

conclusionsTGh was lower in obese AA adolescents with a family history of type 2 diabetes and a significant correlation occurred between TGh and leptin and TGh and insulin during OGGT at specific time points in our obese group. These findings indicate that insulin resistant obese AA adolescents have impaired ghrelin suppression.

Indexed as

Black or African AmericanGlucose Tolerance TestAdolescentCase-Control StudiesChildFastingFemaleGhrelinHumansInsulinLeptinMaleObesityRadioimmunoassayYoung AdultGhrelinInsulinLeptin

Identifiers

PMID24392605
PMCPMC4492798
OpenAlexW2401638461

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.