ArticleBioMed research international2013
Analysis of structures, functions, and epitopes of cysteine protease from Spirometra erinaceieuropaei Spargana.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Epidemiology, Diagnosis, and Prevention of Sparganosis in Asia.Animals : an open access journal from MDPI · 2022Review
- Bioinformatics analysis of structures and ligand-bindings of predicted zymogen granule protein observed on Bali cattle (Journal of advanced veterinary and animal research · 2021Article
- Genome-wide survey of soybean papain-like cysteine proteases and their expression analysis in root nodule symbiosis.BMC plant biology · 2020Article
- Characterization of TwoFrontiers in microbiology · 2018Article
- Serodiagnosis of sparganosis by ELISA using recombinant cysteine protease of Spirometra erinaceieuropaei spargana.Parasitology research · 2015Article
- Characterization of Spirometra erinaceieuropaei Plerocercoid Cysteine Protease and Potential Application for Serodiagnosis of Sparganosis.PLoS neglected tropical diseases · 2015Article
- Protein sequence classification with improved extreme learning machine algorithms.BioMed research international · 2014Article
- The genome of the sparganosis tapeworm Spirometra erinaceieuropaei isolated from the biopsy of a migrating brain lesion.Genome biology · 2014Article
- Cloning and Expression of a NewIranian journal of parasitologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spirometra erinaceieuropaei cysteine protease (SeCP) in sparganum ES proteins recognized by early infection sera was identified by MALDI-TOF/TOF-MS. The aim of this study was to predict the structures and functions of SeCP protein by using the full length cDNA sequence of SeCP gene with online sites and software programs. The SeCP gene sequence was of 1 053 bp length with a 1011 bp biggest ORF encoding 336-amino acid protein with a complete cathepsin propeptide inhibitor domain and a peptidase C1A conserved domain. The predicted molecular weight and isoelectric point of SeCP were 37.87 kDa and 6.47, respectively. The SeCP has a signal peptide site and no transmembrane domain, located outside the membrane. The secondary structure of SeCP contained 8 α -helixes, 7 β -strands, and 20 coils. The SeCP had 15 potential antigenic epitopes and 19 HLA-I restricted epitopes. Based on the phylogenetic analysis of SeCP, S. erinaceieuropaei has the closest evolutionary status with S. mansonoides. SeCP was a kind of proteolytic enzyme with a variety of biological functions and its antigenic epitopes could provide important insights on the diagnostic antigens and target molecular of antisparganum drugs.
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