ArticleFrontiers in cellular and infection microbiology2013
Role of transition metal exporters in virulence: the example of Neisseria meningitidis.
Article in Frontiers in cellular and infection microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Trace metal elements: a bridge between host and intestinal microorganisms.Science China. Life sciences · 2023Review
- Zinc Essentiality, Toxicity, and Its Bacterial Bioremediation: A Comprehensive Insight.Frontiers in microbiology · 2022Review
- Article
- The Role of Zinc in Gliotoxin Biosynthesis ofInternational journal of molecular sciences · 2019Article
- PmtA functions as a ferrous iron and cobalt efflux pump inEmerging microbes & infections · 2019Article
- Transition Metals and Virulence in Bacteria.Annual review of genetics · 2016Review
- Transcriptional profiling of Klebsiella pneumoniae defines signatures for planktonic, sessile and biofilm-dispersed cells.BMC genomics · 2016Article
- Common Cell Shape Evolution of Two Nasopharyngeal Pathogens.PLoS genetics · 2015Article
- The ins and outs of bacterial iron metabolism.Molecular microbiology · 2014Review
- Metal economy in host-microbe interactions.Frontiers in cellular and infection microbiology · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transition metals such as iron, manganese, and zinc are essential micronutrients for bacteria. However, at high concentration, they can generate non-functional proteins or toxic compounds. Metal metabolism is therefore regulated to prevent shortage or overload, both of which can impair cell survival. In addition, equilibrium among these metals has to be tightly controlled to avoid molecular replacement in the active site of enzymes. Bacteria must actively maintain intracellular metal concentrations to meet physiological needs within the context of the local environment. When intracellular buffering capacity is reached, they rely primarily on membrane-localized exporters to maintain metal homeostasis. Recently, several groups have characterized new export systems and emphasized their importance in the virulence of several pathogens. This article discusses the role of export systems as general virulence determinants. Furthermore, it highlights the contribution of these exporters in pathogens emergence with emphasis on the human nasopharyngeal colonizer Neisseria meningitidis.
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Registered trials
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