ReviewCurrent nutrition reports2012
Gene-Lifestyle Interactions in Obesity.
Review in Current nutrition reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Long-term effects of bariatric surgery on type II diabetes, hypertension and hyperlipidemia: a meta-analysis and meta-regression study with 5-year follow-up.Obesity surgery · 2015Pooled it
- Polyphenols intake and expression of insulin signaling genes in adipose tissue of obese adults: a cross-sectional study.Scientific reports · 2026Article
- How does body mass influence inhibitory control? Event-related potentials evidence across the full BMI spectrum.Experimental brain research · 2026Article
- Expression of CD73 and VEGF in salivary gland carcinomas: associations with clinicopathological characteristics in Vietnamese population.BMC cancer · 2025Article
- Reverse epidemiology of obesity paradox: Fact or fiction?Physiological reports · 2024Review
- Associations of Lifestyle and Genetic Risks with Obesity and Related Chronic Diseases in the UK Biobank: A Prospective Cohort Study.The American journal of clinical nutrition · 2024Article
- Article
- Mechanisms and treatment of obesity-related hypertension-Part 1: Mechanisms.Clinical kidney journal · 2024Review
- DNA methylation: a potential mediator between air pollution and metabolic syndrome.Clinical epigenetics · 2022Review
- Dietary branched-chain amino acids and odds of obesity among immigrant Filipino women: the Filipino women's diet and health study (FiLWHEL).BMC public health · 2022Article
- Synergizing Mouse and Human Studies to Understand the Heterogeneity of Obesity.Advances in nutrition (Bethesda, Md.) · 2021Review
- Lifestyle Genetics-Based Reports in the Treatment of Obesity.Archives of Razi Institute · 2021Review
- Interaction of Neighborhood and Genetic Risk on Waist Circumference in African-American Adults: A Longitudinal Study.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2021Article
- Genome-wide association analyses identify genotype-by-environment interactions of growth traits in Simmental cattle.Scientific reports · 2021Article
- Diet-Dependent Changes of the DNA Methylome Using a Göttingen Minipig Model for Obesity.Frontiers in genetics · 2021Article
- Expression profiling and analysis of some miRNAs in subcutaneous white adipose tissue during development of obesity.Genes & nutrition · 2020Article
- Genome-wide association study of morbid obesity in Han Chinese.BMC genetics · 2019Article
- Epigenetic silencing of the ANKRD26 gene correlates to the pro-inflammatory profile and increased cardio-metabolic risk factors in human obesity.Clinical epigenetics · 2019Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a complex multifaceted disease resulting from interactions between genetics and lifestyle. The proportion of phenotypic variance ascribed to genetic variance is 0.4 to 0.7 for obesity and recent years have seen considerable success in identifying disease-susceptibility variants. Although with the advent of genome-wide association studies the list of genetic variants predisposing to obesity has significantly increased the identified variants only explain a fraction of disease heritability. Studies of gene-environment interactions can provide more insight into the biological mechanisms involved in obesity despite the challenges associated with such designs. Epigenetic changes that affect gene function without DNA sequence modifications may be a key factor explaining interindividual differences in obesity, with both genetic and environmental factors influencing the epigenome. Disentangling the relative contributions of genetic, environmental and epigenetic marks to the establishment of obesity is a major challenge given the complex interplay between these determinants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.