ArticlePloS one2014
The 3D structure of the apical complex and association with the flagellar apparatus revealed by serial TEM tomography in Psammosa pacifica, a distant relative of the Apicomplexa.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Adaptations and metabolic evolution of myzozoan protists across diverse lifestyles and environments.Microbiology and molecular biology reviews : MMBR · 2024Review
- Multiple parallel origins of parasitic Marine Alveolates.Nature communications · 2023Article
- Toxoplasma ERK7 protects the apical complex from premature degradation.The Journal of cell biology · 2023Article
- Cryo-tomography reveals rigid-body motion and organization of apicomplexan invasion machinery.Nature communications · 2023Article
- Refractile bodies ofFrontiers in cellular and infection microbiology · 2023Article
- Ultrastructure of Myzocytosis and Cyst Formation, and the Role of Actin in Tubular Tether Formation inPathogens (Basel, Switzerland) · 2022Article
- Nutrient Acquisition and Attachment Strategies in Basal Lineages: A Tough Nut to Crack in the Evolutionary Puzzle of Apicomplexa.Microorganisms · 2021Review
- Molecular characterization of the conoid complex in Toxoplasma reveals its conservation in all apicomplexans, including Plasmodium species.PLoS biology · 2021Article
- Multivalent Interactions Drive themBio · 2021Article
- Loss of a conserved MAPK causes catastrophic failure in assembly of a specialized cilium-like structure inMolecular biology of the cell · 2020Article
- Article
- Single cell genomics of uncultured marine alveolates shows paraphyly of basal dinoflagellates.The ISME journal · 2018Article
- Evolutionary Trends of Perkinsozoa (Alveolata) Characters Based on Observations of Two New Genera of Parasitoids of dinoflagellates,Frontiers in microbiology · 2017Article
- SAS6-like protein in Plasmodium indicates that conoid-associated apical complex proteins persist in invasive stages within the mosquito vector.Scientific reports · 2016Article
- The Conoid Associated Motor MyoH Is Indispensable for Toxoplasma gondii Entry and Exit from Host Cells.PLoS pathogens · 2016Article
- Factors mediating plastid dependency and the origins of parasitism in apicomplexans and their close relatives.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Targeting Toxoplasma tubules: tubulin, microtubules, and associated proteins in a human pathogen.Eukaryotic cell · 2015Review
- The apical complex provides a regulated gateway for secretion of invasion factors in Toxoplasma.PLoS pathogens · 2014Article
- A Comparative Overview of the Flagellar Apparatus of Dinoflagellate, Perkinsids and Colpodellids.Microorganisms · 2014Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The apical complex is one of the defining features of apicomplexan parasites, including the malaria parasite Plasmodium, where it mediates host penetration and invasion. The apical complex is also known in a few related lineages, including several non-parasitic heterotrophs, where it mediates feeding behaviour. The origin of the apical complex is unclear, and one reason for this is that in apicomplexans it exists in only part of the life cycle, and never simultaneously with other major cytoskeletal structures like flagella and basal bodies. Here, we used conventional TEM and serial TEM tomography to reconstruct the three dimensional structure of the apical complex in Psammosa pacifica, a predatory relative of apicomplexans and dinoflagellates that retains the archetype apical complex and the flagellar apparatus simultaneously. The P. pacifica apical complex is associated with the gullet and consists of the pseudoconoid, micronemes, and electron dense vesicles. The pseudoconoid is a convex sheet consisting of eight short microtubules, plus a band made up of microtubules that originate from the flagellar apparatus. The flagellar apparatus consists of three microtubular roots. One of the microtubular roots attached to the posterior basal body is connected to bypassing microtubular strands, which are themselves connected to the extension of the pseudoconoid. These complex connections where the apical complex is an extension of the flagellar apparatus, reflect the ancestral state of both, dating back to the common ancestor of apicaomplexans and dinoflagellates.
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