ArticlePloS one2013
Functional annotation of conserved hypothetical proteins from Haemophilus influenzae Rd KW20.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 106 citations in OpenAlex.
- Characterization of hypothetical proteins reveals function modules and virulence factors in Pseudomonas aeruginosa.Nature communications · 2026Article
- Unveiling Putative Functions of Burkholderia pseudomallei K96243 Hypothetical Proteins Via High-Throughput Characterization of Structural Similarities.Interdisciplinary sciences, computational life sciences · 2026Article
- Article
- Structural and Functional Characterization of a Putative Type VI Secretion System Protein inEvolutionary bioinformatics online · 2025Article
- Computational-guided discovery of UDP-glycosyltransferases for lauryl glucoside production using engineered E. coli.Bioresources and bioprocessing · 2024Article
- Functional annotation of Candida albicans hypothetical proteins: a bioinformatics approach.Archives of microbiology · 2024Article
- Distribution patterns and influential factors of pathogenic bacteria in freshwater aquaculture sediments.Environmental science and pollution research international · 2024Article
- Transcriptomic analysis of the inhibition mechanisms againstFrontiers in veterinary science · 2024Article
- Artificial intelligence-driven reverse vaccinology forFrontiers in molecular biosciences · 2024Article
- Computational proteomics analysis ofFrontiers in plant science · 2024Article
- In silico analysis of a novel hypothetical protein (YP_498675.1) from Staphylococcus aureus unravels the protein of tryptophan synthase beta superfamily (Try-synth-beta_ II).Journal, genetic engineering & biotechnology · 2023Article
- Hypothetical Proteins ofMicroorganisms · 2023Article
- Structural and Functional Annotation of Hypothetical Proteins from the Microsporidia SpeciesInternational journal of molecular sciences · 2023Article
- In Silico Functional Characterization of a Hypothetical Protein FromBioinformatics and biology insights · 2023Article
- Targeting Essential Hypothetical Proteins ofBioMed research international · 2023Article
- Structure of the hypothetical protein TTHA1873 from Thermus thermophilus.Acta crystallographica. Section F, Structural biology communications · 2022Article
- Putative Protein Discovery from Microalgal Genomes as a Synthetic Biology Protein Library for Heavy Metal Bio-Removal.Biology · 2022Article
- Hypothetical protein predicted to be tumor suppressor: a protein functional analysis.Genomics & informatics · 2022Article
- Investigating the Functional Role of Hypothetical Proteins From an Antarctic BacteriumFrontiers in genetics · 2022Article
- Functional Annotation of Hypothetical Proteins From theBioinformatics and biology insights · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haemophilus influenzae is a Gram negative bacterium that belongs to the family Pasteurellaceae, causes bacteremia, pneumonia and acute bacterial meningitis in infants. The emergence of multi-drug resistance H. influenzae strain in clinical isolates demands the development of better/new drugs against this pathogen. Our study combines a number of bioinformatics tools for function predictions of previously not assigned proteins in the genome of H. influenzae. This genome was extensively analyzed and found 1,657 functional proteins in which function of 429 proteins are unknown, termed as hypothetical proteins (HPs). Amino acid sequences of all 429 HPs were extensively annotated and we successfully assigned the function to 296 HPs with high confidence. We also characterized the function of 124 HPs precisely, but with less confidence. We believed that sequence of a protein can be used as a framework to explain known functional properties. Here we have combined the latest versions of protein family databases, protein motifs, intrinsic features from the amino acid sequence, pathway and genome context methods to assign a precise function to hypothetical proteins for which no experimental information is available. We found these HPs belong to various classes of proteins such as enzymes, transporters, carriers, receptors, signal transducers, binding proteins, virulence and other proteins. The outcome of this work will be helpful for a better understanding of the mechanism of pathogenesis and in finding novel therapeutic targets for H. influenzae.
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