ArticlePloS one2013
Ovocalyxin-36 is a pattern recognition protein in chicken eggshell membranes.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- In-vitro and in-vivo assessment of biocompatibility and efficacy of ostrich eggshell membrane combined with platelet-rich plasma in Achilles tendon regeneration.Scientific reports · 2025Article
- Synthesis and Assessment of Antimicrobial Composites of Ag Nanoparticles or AgNOMolecules (Basel, Switzerland) · 2023Article
- Properties, Genetics and Innate Immune Function of the Cuticle in Egg-Laying Species.Frontiers in immunology · 2022Review
- Antimicrobial Proteins and Peptides in Avian Eggshell: Structural Diversity and Potential Roles in Biomineralization.Frontiers in immunology · 2022Review
- Concomitant Morphological Modifications of the Avian Eggshell, Eggshell Membranes and the Chorioallantoic Membrane During Embryonic Development.Frontiers in physiology · 2022Article
- Proteomic Analysis of Chicken Chorioallantoic Membrane (CAM) during Embryonic Development Provides Functional Insight.BioMed research international · 2022Article
- Avian Eggshell Membrane as a Novel Biomaterial: A Review.Foods (Basel, Switzerland) · 2021Review
- Effect of organic and inorganic dietary selenium supplementation on gene expression in oviduct tissues and Selenoproteins gene expression in Lohman Brown-classic laying hens.BMC veterinary research · 2021Article
- Avian eggshell biomineralization: an update on its structure, mineralogy and protein tool kit.BMC molecular and cell biology · 2021Review
- Evolution of the Avian Eggshell Biomineralization Protein Toolkit - New Insights From Multi-Omics.Frontiers in genetics · 2021Review
- Dietary cadmium chloride impairs shell biomineralization by disrupting the metabolism of the eggshell gland in laying hens.Journal of animal science · 2020Article
- The extracellular matrix of eggshell displays anti-inflammatory activities through NF-κB in LPS-triggered human immune cells.Journal of inflammation research · 2017Article
- Article
- Arabidopsis LBP/BPI related-1 and -2 bind to LPS directly and regulate PR1 expression.Scientific reports · 2016Article
- An Efficient Method for Co-purification of Eggshell Matrix Proteins OC-17, OC-116, and OCX-36.Korean journal for food science of animal resources · 2016Article
- Water-soluble egg membrane enhances the immunoactivating properties of anClinical, cosmetic and investigational dermatology · 2016Article
- Proteomic analysis of quail calcified eggshell matrix: a comparison to chicken and turkey eggshell proteomes.Proteome science · 2015Article
- The calcified eggshell matrix proteome of a songbird, the zebra finch (Taeniopygia guttata).Proteome science · 2015Article
- How Egg Case Proteins Can Protect Cuttlefish Offspring?PloS one · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The avian eggshell membranes are essential elements in the fabrication of the calcified shell as a defense against bacterial penetration. Ovocalyxin-36 (OCX-36) is an abundant avian eggshell membrane protein, which shares protein sequence homology to bactericidal permeability-increasing protein (BPI), lipopolysaccharide-binding protein (LBP) and palate, lung and nasal epithelium clone (PLUNC) proteins. We have developed an efficient method to extract OCX-36 from chicken eggshell membranes for purification with cation and anion exchange chromatographies. Purified OCX-36 protein exhibited lipopolysaccharide (LPS) binding activity and bound lipopolysaccharide (LPS) from Escherichia coli O111:B4 in a dose-dependent manner. OCX-36 showed inhibitory activity against growth of Staphylococcus aureus ATCC 6538. OCX-36 single nucleotide polymorphisms (SNPs) were verified at cDNA 211 position and the corresponding proteins proline-71 (Pro-71) or serine-71 (Ser-71) were purified from eggs collected from genotyped hens. A significant difference between Pro-71 and Ser-71 OCX-36 for S. aureus lipoteichoic acid (LTA) binding activity was detected. The current study is a starting point to understand the innate immune role that OCX-36 may play in protection against bacterial invasion of both embryonated eggs (relevant to avian reproductive success) and unfertilized table eggs (relevant to food safety).
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