ArticlePloS one2013
In vitro determination of drug transfer from drug-coated balloons.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy and safety of drug-coated balloon in the treatment of acute myocardial infarction: a meta-analysis of randomized controlled trials.Scientific reports · 2022Pooled it
- Effect of Drug-Coated Balloon in Side Branch Protection forFrontiers in cardiovascular medicine · 2021Pooled it
- Outcomes of Drug-Coated Balloon Versus Drug-Eluting Stent for In-Stent Restenosis and De-Novo Lesions: A Meta-Analysis of Randomized Controlled Trials.Health science reports · 2026Article
- Numerical Simulation and Optimization of Drug-Coated Balloon Inflation for Vascular Stenosis.Bioengineering (Basel, Switzerland) · 2026Article
- Drug-Coated Balloons in Coronary Bifurcation Disease: A State-of-the-Art Review.Journal of personalized medicine · 2026Review
- A Novel In Silico-Ex Vivo Model for Correlating Coating Transfer to Tissue with Local Drug-Coated Balloon-Vessel Contact Pressures.Annals of biomedical engineering · 2025Article
- Drug Loss at Arterial Bends Can Dominate Off-Target Drug Delivery by Paclitaxel-Coated Balloons.Pharmaceutics · 2025Article
- Unveiling the population genetic structure of Iranian horses breeds by whole-genome resequencing analysis.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- Plaque heterogeneity and the spatial distributions of its components dictate drug-coated balloon therapy.Scientific reports · 2024Article
- Understudied factors in drug-coated balloon design and evaluation: A biophysical perspective.Bioengineering & translational medicine · 2023Review
- Precision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease.Scientific reports · 2021Article
- Downstream Paclitaxel Released Following Drug-Coated Balloon Inflation and Distal Limb Wound Healing in Swine.JACC. Basic to translational science · 2021Article
- Systematic evaluation of particle loss during handling in the percutaneous transluminal angioplasty for eight different drug-coated balloons.Scientific reports · 2020Article
- Surface Modification Using Ultraviolet-Ozone Treatment Enhances Acute Drug Transfer in Drug-Coated Balloon Therapy.Langmuir : the ACS journal of surfaces and colloids · 2020Article
- Pre-Clinical Investigation of Keratose as an Excipient of Drug Coated Balloons.Molecules (Basel, Switzerland) · 2020Article
- Necrotic leg ulcers secondary to hydrophilic polymer gel emboli.Journal of vascular surgery cases and innovative techniques · 2019Article
- Article
- HPLC-MS/MS method for quantification of paclitaxel from keratin containing samples.Journal of pharmaceutical and biomedical analysis · 2017Article
- Understanding the Mechanism of Drug Transfer and Retention of Drug-Coated Balloons.Journal of cardiovascular pharmacology and therapeuticsArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug-coated balloons are medical devices designed to locally deliver drug to diseased segments of the vessel wall. For these dosage forms, drug transfer to the vessel wall needs to be examined in detail, since drug released into the blood is cleared from the site. In order to examine drug transfer, a new in vitro setup was developed combining the estimation of drug loss during advancement to the site of application in a model coronary artery pathway with a hydrogel compartment representing, as a very simplified model, the vessel wall. The transfer of fluorescent model substances as well as the drug paclitaxel from coated balloons to the simulated vessel wall was evaluated using this method. The model was suitable to quantify the fractions transferred to the hydrogel and also to qualitatively assess distribution patterns in the hydrogel film. In the case of fluorescein sodium, rhodamin b and paclitaxel, vast amounts of the coated substance were lost during the simulated passage and only very small fractions of about 1% of the total load were transferred to the gel. This must be attributed to good water solubility of the fluorescent substances and the mechanical instability of the paclitaxel coating. Transfer of the hydrophobic model substance triamterene was however nearly unaffected by the preliminary tracking procedure with transferred fractions ranging from 8% to 14%. Analysis of model substance distribution yielded inhomogeneous distributions indicating that the coating was not evenly distributed on the balloon surface and that a great fraction of the coating liquid did not penetrate the folds of the balloon. This finding is contradictory to the generally accepted assumption of a drug depot inside the folds and emphasizes the necessity to thoroughly characterize in vitro performance of drug-coated balloons to support the very promising clinical data.
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