ArticlePloS one2013
Electroacupuncture at ST36 ameliorates gastric emptying and rescues networks of interstitial cells of Cajal in the stomach of diabetic rats.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- The efficacy of transcutaneous electrical acupoint stimulation on postoperative nausea and vomiting after laparoscopic surgery: a meta-analysis of randomized controlled trials.Frontiers in medicine · 2026Pooled it
- Electroacupuncture at ST-36 Protects Interstitial Cells of Cajal via Sustaining Heme Oxygenase-1 Positive M2 Macrophages in the Stomach of Diabetic Mice.Oxidative medicine and cellular longevity · 2018Trial
- Alternative Therapeutic Approaches in the Management of Gastroparesis: A Systematic Review.Diseases (Basel, Switzerland) · 2026Review
- Electroacupuncture protects gastric Cajal cells by reducing macrophage pyroptosis in diabetic gastroparesis.World journal of diabetes · 2026Article
- Review
- New insights into muscularis macrophages in the gut: from their origin to therapeutic targeting.Immunologic research · 2023Review
- Possible organ-protective effects of renal denervation: insights from basic studies.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- Noninvasive electrical neuromodulation for gastrointestinal motility disorders.Expert review of gastroenterology & hepatology · 2023Review
- Non-invasive neuromodulation: an emerging intervention for visceral pain in gastrointestinal disorders.Bioelectronic medicine · 2023Review
- The Probiotic Combination ofNutrients · 2023Article
- Effects of acupuncture on gastrointestinal diseases and its underlying mechanism: a literature review of animal studies.Frontiers in medicine · 2023Review
- Metabolism modulation in rat tissues in response to point specificity of electroacupuncture.Scientific reports · 2022Article
- Article
- Management of Dyspepsia and Gastroparesis in Patients with Diabetes. A Clinical Point of View in the Year 2021.Journal of clinical medicine · 2021Review
- Gastric Electrical Pacing Reduces Apoptosis of Interstitial Cells of Cajal via Antioxidative Stress Effect Attributing to Phenotypic Polarization of M2 Macrophages in Diabetic Rats.Oxidative medicine and cellular longevity · 2021Article
- Electroacupuncture Regularizes Gastric Contraction and Reduces Apoptosis of Interstitial Cells of Cajal in Diabetic Rats.Frontiers in physiology · 2021Article
- Electroacupuncture Relieves Suppression of Autophagy in Interstitial Cells of Cajal of Diabetic Gastroparesis Rats.Canadian journal of gastroenterology & hepatology · 2020Article
- Electroacupuncture at ST36 Increases Bone Marrow-Derived Interstitial Cells of Cajal via the SDF-1/CXCR4 and mSCF/Kit-ETV1 Pathways in the Stomach of Diabetic Mice.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Long-Pulse Gastric Electrical Stimulation Repairs Interstitial Cells of Cajal and Smooth Muscle Cells in the Gastric Antrum of Diabetic Rats.Gastroenterology research and practice · 2018Article
- Acupoint Therapy on Diabetes Mellitus and Its Common Chronic Complications: A Review of Its Mechanisms.BioMed research international · 2018Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depletion of interstitial cells of Cajal (ICC) is certified in the stomach of diabetic patients. Though electroacupuncture (EA) at ST36 is an effective therapy to regulate gastric motility, the mechanisms of EA at ST36 on gastric emptying and networks of ICC remain to be elucidated. The aims of this study were to investigate the effects of EA on gastric emptying and on the alterations of ICC networks. Rats were randomized into the control, diabetic rats (DM), diabetic rats with sham EA (DM+SEA), diabetic rats with low frequency EA (DM+LEA) and diabetic rats with high frequency EA groups (DM+HEA). The expression of c-kit in each layer of gastric wall was assessed by western blotting. The proliferation of ICC was identified by immunolabeling of c-kit and Ki67 as the apoptosis of ICC was examined by TUNEL staining. The results were as follows: (1) Gastric emptying was severely delayed in the DM group, but accelerated in the LEA and HEA group, especially in the LEA group. (2) The expression of c-kit in each layer was reduced apparently in the DM group, but also up-regulated in the LEA and HEA group. (3) Plentiful proliferated ICC (c-kit+/Ki67+) forming bushy networks with c-kit+ cells were observed in the LEA and HEA group, while the apoptotic cells (c-kit+/TUNEL+) were hardly captured in the LEA and HEA group. Collectively, low and high frequency EA at ST36 rescue the damaged networks of ICC by inhibiting the apoptosis and enhancing the proliferation in the stomach of diabetic rats, resulting in an improved gastric emptying.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.