ArticlePloS one2013
To investigate the necessity of STRA6 upregulation in T cells during T cell immune responses.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
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- Therapeutic Uses of Retinol and Retinoid-Related Antioxidants.Molecules (Basel, Switzerland) · 2025Review
- Immunometabolic effects ofImmunometabolism (Cobham, Surrey) · 2024Review
- Functional investigation of five R2R3-MYB transcription factors associated with wood development in Eucalyptus using DAP-seq-ML.Plant molecular biology · 2023Article
- Vitamin A: too good to be bad?Frontiers in pharmacology · 2023Review
- Mice Lacking the Systemic Vitamin A Receptor RBPR2 Show Decreased Ocular Retinoids and Loss of Visual Function.Nutrients · 2022Article
- The vitamin A transporter STRA6 adjusts the stoichiometry of chromophore and opsins in visual pigment synthesis and recycling.Human molecular genetics · 2022Article
- The role of β-carotene and vitamin A in atherogenesis: Evidences from preclinical and clinical studies.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2020Review
- Differential stromal reprogramming in benign and malignant naturally occurring canine mammary tumours identifies disease-modulating stromal components.Scientific reports · 2020Article
- Adipokine RBP4 drives ovarian cancer cell migration.Journal of ovarian research · 2018Article
- New insights and changing paradigms in the regulation of vitamin A metabolism in development.Wiley interdisciplinary reviews. Developmental biology · 2017Review
- Armc5 deletion causes developmental defects and compromises T-cell immune responses.Nature communications · 2017Article
- Transport of vitamin A across blood-tissue barriers is facilitated by STRA6.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- STRA6: role in cellular retinol uptake and efflux.Hepatobiliary surgery and nutrition · 2015Review
- Is retinol binding protein 4 a link between adiposity and cancer?Hormone molecular biology and clinical investigation · 2015Review
- Production of functional human vitamin A transporter/RBP receptor (STRA6) for structure determination.PloS one · 2015Article
- Holo-retinol-binding protein and its receptor STRA6 drive oncogenic transformation.Cancer research · 2014Article
- STRA6 is critical for cellular vitamin A uptake and homeostasis.Human molecular genetics · 2014Article
- Molecular Mechanisms of Retinoid Receptors in Diabetes-Induced Cardiac Remodeling.Journal of clinical medicine · 2014Review
- The multifaceted nature of retinoid transport and metabolism.Hepatobiliary surgery and nutrition · 2014Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Our earlier study revealed that STRA6 (stimulated by retinoic acid gene 6) was up-regulated within 3 h of TCR stimulation. STRA6 is the high-affinity receptor for plasma retinol-binding protein (RBP) and mediates cellular vitamin A uptake. We generated STRA6 knockout (KO) mice to assess whether such up-regulation was critical for T-cell activation, differentiation and function. STRA6 KO mice under vitamin A sufficient conditions were fertile without apparent anomalies upon visual inspection. The size, cellularity and lymphocyte subpopulations of STRA6 KO thymus and spleen were comparable to those of their wild type (WT) controls. KO and WT T cells were similar in terms of TCR-stimulated proliferation in vitro and homeostatic expansion in vivo. Naive KO CD4 cells differentiated in vitro into Th1, Th2, Th17 as well as regulatory T cells in an analogous manner as their WT counterparts. In vivo experiments revealed that anti-viral immune responses to lymphocytic choriomeningitis virus in KO mice were comparable to those of WT controls. We also demonstrated that STRA6 KO and WT mice had similar glucose tolerance. Total vitamin A levels are dramatically lower in the eyes of KO mice as compared to those of WT mice, but the levels in other organs were not significantly affected after STRA6 deletion under vitamin A sufficient conditions, indicating that the eye is the mouse organ most sensitive to the loss of STRA6. Our results demonstrate that 1) in vitamin A sufficiency, the deletion of STRA6 in T cells does no affect the T-cell immune responses so-far tested, including those depend on STAT5 signaling; 2) STRA6-independent vitamin A uptake compensated the lack of STRA6 in lymphoid organs under vitamin A sufficient conditions in mice; 3) STRA6 is critical for vitamin A uptake in the eyes even in vitamin A sufficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.