ArticleFrontiers in genetics2013
G protein-linked signaling pathways in bipolar and major depressive disorders.
Article in Frontiers in genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 87 citations in OpenAlex.
- A combined study of whole-exome sequencing and structural neuroimaging markers in bipolar disorder.Translational psychiatry · 2026Article
- Excitatory paraventricular thalamus-posterior insular cortex circuit mediates pain-anxiety comorbidity in diabetic neuropathy.Translational psychiatry · 2026Article
- Cellular and proteomic differences associated with lithium response in olfactory neuroepithelium cells of bipolar disorder patients.Molecular medicine (Cambridge, Mass.) · 2025Article
- Neuroprotectin D1 and GPR37 protect against chemotherapy-induced peripheral neuropathy and the transition from acute to chronic pain.Pharmacological research · 2025Article
- Roles of osteocalcin in the central nervous system.CNS neuroscience & therapeutics · 2024Review
- GPR37 and its neuroprotective mechanisms: bridging osteocalcin signaling and brain function.Frontiers in cell and developmental biology · 2024Review
- Identifying candidate genes associated with hippocampal dysfunction in a hemiparkinsonian rat model by transcriptomic profiling.Animal cells and systems · 2024Article
- Orphan G Protein-Coupled Receptor GPR37 as an Emerging Therapeutic Target.ACS chemical neuroscience · 2023Review
- GPRC5B protects osteoarthritis by regulation of autophagy signaling.Acta pharmaceutica Sinica. B · 2023Article
- An epigenome-wide analysis of socioeconomic position and tumor DNA methylation in breast cancer patients.Clinical epigenetics · 2023Article
- Decreased plasma neuropeptides in first-episode schizophrenia, bipolar disorder, major depressive disorder: associations with clinical symptoms and cognitive function.Frontiers in psychiatry · 2023Article
- Impaired Aversive Memory Formation in GPR37L1KO Mice.International journal of molecular sciences · 2022Article
- Pathophysiology of Depression: Stingless Bee Honey Promising as an Antidepressant.Molecules (Basel, Switzerland) · 2022Review
- Osteocalcin Alleviates Lipopolysaccharide-Induced Acute Inflammation via Activation of GPR37 in Macrophages.Biomedicines · 2022Article
- The role of orphan receptor GPR139 in neuropsychiatric behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort.Nature genetics · 2022Article
- Comprehensive Spatial Profile of the Orphan G Protein Coupled Receptor GPRC5B Expression in Mouse Brain.Frontiers in neuroscience · 2022Article
- The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice.International journal of molecular sciences · 2021Article
- Article
- NoRCE: non-coding RNA sets cis enrichment tool.BMC bioinformatics · 2021Article
Corrections and comments
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Authors and funding
18 authors at 9 institutions in 2 countries.
Funding
Abstract
The G-protein linked signaling system (GPLS) comprises a large number of G-proteins, G protein-coupled receptors (GPCRs), GPCR ligands, and downstream effector molecules. G-proteins interact with both GPCRs and downstream effectors such as cyclic adenosine monophosphate (cAMP), phosphatidylinositols, and ion channels. The GPLS is implicated in the pathophysiology and pharmacology of both major depressive disorder (MDD) and bipolar disorder (BPD). This study evaluated whether GPLS is altered at the transcript level. The gene expression in the dorsolateral prefrontal (DLPFC) and anterior cingulate (ACC) were compared from MDD, BPD, and control subjects using Affymetrix Gene Chips and real time quantitative PCR. High quality brain tissue was used in the study to control for confounding effects of agonal events, tissue pH, RNA integrity, gender, and age. GPLS signaling transcripts were altered especially in the ACC of BPD and MDD subjects. Transcript levels of molecules which repress cAMP activity were increased in BPD and decreased in MDD. Two orphan GPCRs, GPRC5B and GPR37, showed significantly decreased expression levels in MDD, and significantly increased expression levels in BPD. Our results suggest opposite changes in BPD and MDD in the GPLS, "activated" cAMP signaling activity in BPD and "blunted" cAMP signaling activity in MDD. GPRC5B and GPR37 both appear to have behavioral effects, and are also candidate genes for neurodegenerative disorders. In the context of the opposite changes observed in BPD and MDD, these GPCRs warrant further study of their brain effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.