Evidence map›Paper›PMID 24391602›Full record

ReviewFrontiers in psychiatry2013

Mismatch negativity: translating the potential.

Juanita Todd, Lauren Harms, Ulrich Schall, Patricia T Michie

Abstract readReview
In one paragraph

Review in Frontiers in psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  14. Opportunities for use of neuroimaging in de-risking drug development and improving clinical outcomes in psychiatry: an industry perspective.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Juanita ToddSchool of Psychology, University of Newcastle , Callaghan, NSW , Australia ; Priority Research Centre for Brain and Mental Health, University of Newcastle , Callaghan, NSW , Australia ; Schizophrenia Research Institute , Darlinghurst, NSW , Australia ; Hunter Medical Research Institute , Newcastle, NSW , Australia.
Lauren HarmsSchool of Psychology, University of Newcastle , Callaghan, NSW , Australia ; Priority Research Centre for Brain and Mental Health, University of Newcastle , Callaghan, NSW , Australia ; Schizophrenia Research Institute , Darlinghurst, NSW , Australia ; Hunter Medical Research Institute , Newcastle, NSW , Australia.
Ulrich SchallPriority Research Centre for Brain and Mental Health, University of Newcastle , Callaghan, NSW , Australia ; Schizophrenia Research Institute , Darlinghurst, NSW , Australia ; Hunter Medical Research Institute , Newcastle, NSW , Australia ; School of Medicine and Public Health, University of Newcastle , Callaghan, NSW , Australia.
Patricia T MichieSchool of Psychology, University of Newcastle , Callaghan, NSW , Australia ; Priority Research Centre for Brain and Mental Health, University of Newcastle , Callaghan, NSW , Australia ; Schizophrenia Research Institute , Darlinghurst, NSW , Australia ; Hunter Medical Research Institute , Newcastle, NSW , Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mismatch negativity (MMN) component of the auditory event-related potential has become a valuable tool in cognitive neuroscience. Its reduced size in persons with schizophrenia is of unknown origin but theories proposed include links to problems in experience-dependent plasticity reliant on N-methyl-d-aspartate glutamate receptors. In this review we address the utility of this tool in revealing the nature and time course of problems in perceptual inference in this illness together with its potential for use in translational research testing animal models of schizophrenia-related phenotypes. Specifically, we review the reasons for interest in MMN in schizophrenia, issues pertaining to the measurement of MMN, its use as a vulnerability index for the development of schizophrenia, the pharmacological sensitivity of MMN and the progress in developing animal models of MMN. Within this process we highlight the challenges posed by knowledge gaps pertaining to the tool and the pharmacology of the underlying system.

Indexed as

auditory event-related potentialmismatch negativityNMDANMDARschizophreniasynaptic plasticity

Identifiers

PMID24391602
PMCPMC3866657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.