ArticleFrontiers in aging neuroscience2013
Overall reductions in functional brain activation are associated with falls in older adults: an fMRI study.
Article in Frontiers in aging neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Can two multimodal psychomotor exercise programs improve attention, affordance perception, and balance in community dwellings at risk of falling? A randomized controlled trial.BMC public health · 2022Trial
- Sweat the Fall Stuff: Physical Activity Moderates the Association of White Matter Hyperintensities With Falls Risk in Older Adults.Frontiers in human neuroscience · 2021Article
- Brain activity associated with Dual-task performance of Ankle motor control during cognitive challenge.Brain and behavior · 2019Article
- The Neurocognitive Basis for Impaired Dual-Task Performance in Senior Fallers.Frontiers in aging neuroscience · 2016Article
- The role of postural instability/gait difficulty and fear of falling in predicting falls in non-demented older adults.Archives of gerontology and geriatricsArticle
- White Matter Volume Mediates the Relationship Between Self-Efficacy and Mobility in Older Women.Experimental aging researchArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Falls are a common geriatric condition, and while impaired cognitive function has been identified as a key risk factor, the neural correlates that contribute to reduced executive functioning and falls currently remain unknown. In this study, community-dwelling adults aged 65-75 years were divided into two groups based on their recent history of falls (fallers versus non-fallers). All participants completed the Flanker task during functional magnetic resonance imaging (fMRI). We examined the hemodynamic response of congruent and incongruent trials separately in order to separate the relative contribution of each trial type as a function of falls history. We found that fallers exhibited a smaller difference in functional activation between congruent and incongruent trials relative to non-fallers, as well as an overall reduction in level of blood-oxygen-level dependent response. Of particular note, the medial frontal gyrus - a region implicated in motor planning - demonstrated hypo-activation in fallers, providing evidence that the prefrontal cortex might play a central role in falls risk in older adults.
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Registered trials
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