ArticleFrontiers in neural circuits2013
The contribution of δ subunit-containing GABAA receptors to phasic and tonic conductance changes in cerebellum, thalamus and neocortex.
Article in Frontiers in neural circuits, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- δ-Containing GABAJournal of neurophysiology · 2025Article
- Extrasynaptic δGABAA receptors mediate resistance to migraine-like phenotype in rats.The journal of headache and pain · 2024Article
- δ subunit-containing GABAThe Journal of physiology · 2020Article
- Chemogenetic Isolation Reveals Synaptic Contribution of δ GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The Cerebellar GABAHandbook of experimental pharmacology · 2018Article
- Chloride Homeostasis in Neurons With Special Emphasis on the Olivocerebellar System: Differential Roles for Transporters and Channels.Frontiers in cellular neuroscience · 2018Review
- Fast and Slow Inhibition in the Visual Thalamus Is Influenced by Allocating GABAFrontiers in cellular neuroscience · 2017Article
- Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus.Nature communications · 2016Article
- Sex Differences in GABAA Signaling in the Periaqueductal Gray Induced by Persistent Inflammation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Methyl CpG Binding Protein 2 Gene Disruption Augments Tonic Currents of γ-Aminobutyric Acid Receptors in Locus Coeruleus Neurons: IMPACT ON NEURONAL EXCITABILITY AND BREATHING.The Journal of biological chemistry · 2015Article
- Basal ganglia-thalamus and the "crowning enigma".Frontiers in neural circuits · 2015Review
- GABAρ subunits confer a bicuculline-insensitive component to GFAP+ cells of cerebellum.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Anesthetic action on extra-synaptic receptors: effects in neural population models of EEG activity.Frontiers in systems neuroscience · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have made use of the δ subunit-selective allosteric modulator DS2 (4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridine-3-yl benzamide) to assay the contribution of δ-GABAARs to tonic and phasic conductance changes in the cerebellum, thalamus and neocortex. In cerebellar granule cells, an enhancement of the tonic conductance was observed for DS2 and the orthosteric agonist THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol). As expected, DS2 did not alter the properties of GABAA receptor-mediated inhibitory postsynaptic synaptic conductances (IPSCs) supporting a purely extrasynaptic role for δ-GABAARs in cerebellar granule cells. DS2 also enhanced the tonic conductance recorded from thalamic relay neurons of the visual thalamus with no alteration in IPSC properties. However, in addition to enhancing the tonic conductance DS2 also slowed the decay of IPSCs recorded from layer II/III neocortical neurons. A slowing of the IPSC decay also occurred in the presence of the voltage-gated sodium channel blocker TTX. Moreover, under conditions of reduced GABA release the ability of DS2 to enhance the tonic conductance was attenuated. These results indicate that δ-GABAARs can be activated following vesicular GABA release onto neocortical neurons and that the actions of DS2 on the tonic conductance may be influenced by the ambient GABA levels present in particular brain regions.
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