ReviewFrontiers in cellular neuroscience2013
Concepts for regulation of axon integrity by enwrapping glia.
Review in Frontiers in cellular neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- WONOEP appraisal: The role of glial cells in focal malformations associated with early onset epilepsies.Epilepsia · 2024Review
- A multi-siteTranslational psychiatry · 2024Article
- Schwann cell interactions during the development of the peripheral nervous system.Developmental neurobiology · 2021Review
- New evidence for secondary axonal degeneration in demyelinating neuropathies.Neuroscience letters · 2021Review
- Mechanical regulation of oligodendrocyte biology.Neuroscience letters · 2020Review
- Detrimental Impact of Energy Drink Compounds on Developing Oligodendrocytes and Neurons.Cells · 2019Article
- Degeneration of Injured Axons and Dendrites Requires Restraint of a Protective JNK Signaling Pathway by the Transmembrane Protein Raw.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Hyperperfusion of Frontal White and Subcortical Gray Matter in Autism Spectrum Disorder.Biological psychiatry · 2019Article
- How changes in white matter might underlie improved reaction time due to practice.Cognitive neuroscience · 2017Review
- Axon degeneration: make the Schwann cell great again.Neural regeneration research · 2017Review
- Review
- Influence of Mechanical Stimuli on Schwann Cell Biology.Frontiers in cellular neuroscience · 2017Review
- Axon degeneration: Linking axonal bioenergetics to myelin.The Journal of cell biology · 2016Article
- Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?Molecular neurobiology · 2016Review
- Glial expression of Swiss cheese (SWS), the Drosophila orthologue of neuropathy target esterase (NTE), is required for neuronal ensheathment and function.Disease models & mechanisms · 2016Article
- Axonal maintenance, glia, exosomes, and heat shock proteins.F1000Research · 2016Review
- Amyloid Dysmetabolism Relates to Reduced Glucose Uptake in White Matter Hyperintensities.Frontiers in neurology · 2016Article
- High-resolution live imaging reveals axon-glia interactions during peripheral nerve injury and repair in zebrafish.Disease models & mechanisms · 2015Article
- Filamentous aggregations of phosphorylated α-synuclein in Schwann cells (Schwann cell cytoplasmic inclusions) in multiple system atrophy.Acta neuropathologica communications · 2015Article
- Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance.Nature neuroscience · 2014Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long axons and their enwrapping glia (EG; Schwann cells (SCs) and oligodendrocytes (OLGs)) form a unique compound structure that serves as conduit for transport of electric and chemical information in the nervous system. The peculiar cytoarchitecture over an enormous length as well as its substantial energetic requirements make this conduit particularly susceptible to detrimental alterations. Degeneration of long axons independent of neuronal cell bodies is observed comparatively early in a range of neurodegenerative conditions as a consequence of abnormalities in SCs and OLGs . This leads to the most relevant disease symptoms and highlights the critical role that these glia have for axon integrity, but the underlying mechanisms remain elusive. The quest to understand why and how axons degenerate is now a crucial frontier in disease-oriented research. This challenge is most likely to lead to significant progress if the inextricable link between axons and their flanking glia in pathological situations is recognized. In this review I compile recent advances in our understanding of the molecular programs governing axon degeneration, and mechanisms of EG's non-cell autonomous impact on axon-integrity. A particular focus is placed on emerging evidence suggesting that EG nurture long axons by virtue of their intimate association, release of trophic substances, and neurometabolic coupling. The correction of defects in these functions has the potential to stabilize axons in a variety of neuronal diseases in the peripheral nervous system and central nervous system (PNS and CNS).
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