ArticleInternational journal of biological sciences2013
Important functional roles of basigin in thymocyte development and T cell activation.
Article in International journal of biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- SARS-CoV-2-associated lymphopenia: possible mechanisms and the role of CD147.Cell communication and signaling : CCS · 2024Review
- The retina-specific basigin isoform does not induce IL-6 expression in mouse monocytes.Molecular vision · 2023Article
- Immunoreactivity of humanized single-chain variable fragment against its functional epitope on domain 1 of CD147.Scientific reports · 2022Article
- CD98-induced CD147 signaling stabilizes the Foxp3 protein to maintain tissue homeostasis.Cellular & molecular immunology · 2021Article
- CD147 regulates antitumor CD8Cellular & molecular immunology · 2021Article
- CD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression.Signal transduction and targeted therapy · 2021Article
- No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor.Scientific reports · 2021Article
- Differential CD147 Functional Epitopes on Distinct Leukocyte Subsets.Frontiers in immunology · 2021Article
- CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGFβ.Cellular & molecular immunology · 2021Article
- CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells.Signal transduction and targeted therapy · 2020Article
- Asthma-associated risk for COVID-19 development.The Journal of allergy and clinical immunology · 2020Review
- Article
- Blockade of Macrophage CD147 Protects Against Foam Cell Formation in Atherosclerosis.Frontiers in cell and developmental biology · 2020Article
- A critical epitope in CD147 facilitates memory CD4Cellular & molecular immunology · 2019Article
- Generation and Characterization of Fibroblast-Specific Basigin Knockout Mice.Molecular biotechnology · 2019Article
- CD147 Promotes CXCL1 Expression and Modulates Liver Fibrogenesis.International journal of molecular sciences · 2018Article
- Targeting CD147 for T to NK Lineage Reprogramming and Tumor Therapy.EBioMedicine · 2017Article
- Regulation of a TGF-β1-CD147 self-sustaining network in the differentiation plasticity of hepatocellular carcinoma cells.Oncogene · 2016Article
- Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners.Journal of biochemistry · 2016Review
- CD147 reinforces [Ca2+]i oscillations and promotes oncogenic progression in hepatocellular carcinoma.Oncotarget · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Basigin is a highly glycosylated transmembrane protein that is expressed in a broad range of tissues and is involved in a number of physiological and pathological processes. However, the in vivo role of basigin remains unknown. To better understand the physiological and pathological functions of basigin in vivo, we generated a conditional null allele by introducing two loxP sites flanking exons 2 and 7 of the basigin gene (Bsg). Bsg(fl/fl) mice were born at the expected Mendelian ratio and showed a similar growth rate compared with wildtype mice. After crossing these mice with Lck-Cre transgenic mice, basigin expression was specifically inactivated in T cells in the resulting Lck-Cre; Bsg(fl/fl) mice. Although the birth and growth rate of Lck-Cre; Bsg(fl/fl) mice were similar to control mice, thymus development was partially arrested in Lck-Cre; Bsg(fl/fl) mice, specifically at the CD4(+)CD8(+) double-positive (DP) and CD4 single-positive (CD4(+)CD8(-), CD4SP) stages. In addition, CD4(+) T cell activation was enhanced upon Concanavalin A (Con A) or anti-CD3/anti-CD28 stimulation but not upon PMA/Ionomycin stimulation in the absence of basigin. Overall, this study provided the first in vivo evidence for the function of basigin in thymus development. Moreover, the successful generation of the conditional null basigin allele provides a useful tool for the study of distinct physiological or pathological functions of basigin in different tissues at different development stages.
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Registered trials
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