ArticleInternational journal of biological sciences2013
C1q-like factor, a target of miR-430, regulates primordial germ cell development in early embryos of Carassius auratus.
Article in International journal of biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 31 citations in OpenAlex.
- Small RNA sequencing reveals sex-related miRNAs inFrontiers in genetics · 2022Article
- Integrated Analysis of miR-430 on Steroidogenesis-Related Gene Expression of Larval Rice Field EelInternational journal of molecular sciences · 2021Article
- The Importance of Small Non-Coding RNAs in Human Reproduction: A Review Article.The application of clinical genetics · 2020Review
- Seminal Plasma Exosomes: Promising Biomarkers for Identification of Male and Pseudo-Males in Cynoglossus semilaevis.Marine biotechnology (New York, N.Y.) · 2019Article
- Divergent Expression Patterns and Function Implications of Four nanos Genes in a Hermaphroditic Fish, Epinephelus coioides.International journal of molecular sciences · 2017Article
- MicroRNAs: From Female Fertility, Germ Cells, and Stem Cells to Cancer in Humans.Stem cells international · 2016Review
- A comprehensive transcriptome provides candidate genes for sex determination/differentiation and SSR/SNP markers in yellow catfish.Marine biotechnology (New York, N.Y.) · 2015Article
- Comparative Transcriptome Analysis of Differentially Expressed Genes and Signaling Pathways between XY and YY Testis in Yellow Catfish.PloS one · 2015Article
- Zebrafish Noxa promotes mitosis in early embryonic development and regulates apoptosis in subsequent embryogenesis.Cell death and differentiation · 2014Article
- Proliferation and resistance difference of a liver-parasitized myxosporean in two different gynogenetic clones of gibel carp.Parasitology research · 2014Article
- Sex-biased miRNAs in gonad and their potential roles for testis development in yellow catfish.PloS one · 2014Article
- Type-IV antifreeze proteins are essential for epiboly and convergence in gastrulation of zebrafish embryos.International journal of biological sciences · 2014Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C1q-like is a significant maternal factor of TNF/C1q super-family, and the abundant protein has been observed in both mature eggs of Carassius auratus and Carassius auratus gibelio, but its biological function in early embryo development has remained unclear. In this study, we firstly revealed a high level of maternal C1q-like transcript existence only in mature eggs of Carassius auratus, whereas no any maternal C1q-like transcript was observed in that of Carassius auratus gibelio. During embryonic development, the C1q-like zygotic expression begins around cardiopalmus stage in embryos of both Carassius auratus and Carassius auratus gibelio. Then, we examined the biological role of C1q-like by morpholino-mediated knockdown in early embryo development. Knockdown of CaOC1q resulted in a significant reduction of primordial germ cells (PGCs) in Carassius auratus, as shown by whole mount in situ hybridization with vasa-specific RNA probe, fluorescence immunostaining of vasa protein, and GFP imaging of the GFP-nanos1-3'UTR mRNA reporter. In vitro and in vivo evidence indicated that a microRNA, miR-430 could repress the C1q-like expression and PGC development. These data suggest that C1q-like should be a direct target of miR-430 and play an essential role in PGC development of Carassius auratus.
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