ArticleGenome biology and evolution2014
Ecology drives the distribution of specialized tyrosine metabolism modules in fungi.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- FAMeDB: A Curated Database for the Analysis of Fungal Aromatic Compound Metabolism.Computational and structural biotechnology journal · 2026Article
- Generalized Gene Cluster Detection Using CLOCI.Methods in molecular biology (Clifton, N.J.) · 2026Article
- CLOCI: unveiling cryptic fungal gene clusters with generalized detection.Nucleic acids research · 2024Article
- Regulation of nutrient utilization in filamentous fungi.Applied microbiology and biotechnology · 2023Review
- Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events.IMA fungus · 2023Article
- Endophyte genomes support greater metabolic gene cluster diversity compared with non-endophytes in Trichoderma.PloS one · 2023Article
- Transcriptome and proteome profiling reveals complex adaptations of Candida parapsilosis cells assimilating hydroxyaromatic carbon sources.PLoS genetics · 2022Article
- Twists and Turns in the Salicylate Catabolism ofmSystems · 2021Article
- Lower Funneling Pathways inFrontiers in microbiology · 2021Article
- Specialized plant biochemistry drives gene clustering in fungi.The ISME journal · 2018Article
- Ecology of Scedosporium Species: Present Knowledge and Future Research.Mycopathologia · 2018Review
- Genomic insights intoStandards in genomic sciences · 2018Article
- Global transcriptional analysis suggests Lasiodiplodia theobromae pathogenicity factors involved in modulation of grapevine defensive response.BMC genomics · 2016Article
- FunGeneClusterS: Predicting fungal gene clusters from genome and transcriptome data.Synthetic and systems biotechnology · 2016Article
- Dimensions of Horizontal Gene Transfer in Eukaryotic Microbial Pathogens.PLoS pathogens · 2015Article
- Clustering of two genes putatively involved in cyanate detoxification evolved recently and independently in multiple fungal lineages.Genome biology and evolution · 2015Article
- Fungal metabolic gene clusters-caravans traveling across genomes and environments.Frontiers in microbiology · 2015Review
- The evolution of fungal metabolic pathways.PLoS genetics · 2014Article
- Fungal biology in the post-genomic era.Fungal biology and biotechnology · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene clusters encoding accessory or environmentally specialized metabolic pathways likely play a significant role in the evolution of fungal genomes. Two such gene clusters encoding enzymes associated with the tyrosine metabolism pathway (KEGG #00350) have been identified in the filamentous fungus Aspergillus fumigatus. The l-tyrosine degradation (TD) gene cluster encodes a functional module that facilitates breakdown of the phenolic amino acid, l-tyrosine through a homogentisate intermediate, but is also involved in the production of pyomelanin, a fungal pathogenicity factor. The gentisate catabolism (GC) gene cluster encodes a functional module likely involved in phenolic compound degradation, which may enable metabolism of biphenolic stilbenes in multiple lineages. Our investigation of the evolution of the TD and GC gene clusters in 214 fungal genomes revealed spotty distributions partially shaped by gene cluster loss and horizontal gene transfer (HGT). Specifically, a TD gene cluster shows evidence of HGT between the extremophilic, melanized fungi Exophiala dermatitidis and Baudoinia compniacensis, and a GC gene cluster shows evidence of HGT between Sordariomycete and Dothideomycete grass pathogens. These results suggest that the distribution of specialized tyrosine metabolism modules is influenced by both the ecology and phylogeny of fungal species.
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