ArticleJournal of magnetic resonance imaging : JMRI2014
Estimation of the absolute shear stiffness of human lung parenchyma using (1) H spin echo, echo planar MR elastography.
Article in Journal of magnetic resonance imaging : JMRI, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Quantitative equivalence of Quantitative Imaging Biomarkers Alliance (QIBA)-2023- and QIBA-2020-compliant MR elastography protocols for liver stiffness assessment.Abdominal radiology (New York) · 2026Article
- The mechano-immunological barrier in fibrosis-associated lung cancer: targeting matrix stiffness and the Piezo1 axis for microenvironment normalization.Frontiers in pharmacology · 2026Review
- Imaging the Lung in ARDS: A Primer.Respiratory care · 2024Review
- Magnetic Resonance Elastography and Computational Modeling Identify Heterogeneous Lung Biomechanical Properties during Cystic Fibrosis.Research square · 2024Article
- Comparison of spin-echo echo planar imaging and gradient-recalled echo sequences in magnetic resonance elastography of liver at 1.5T same MRI scanner.Abdominal radiology (New York) · 2024Article
- Mapping the strain-stiffening behavior of the lung and lung cancer at microscale resolution using the crystal ribcage.Frontiers in network physiology · 2024Article
- Reverberant magnetic resonance elastographic imaging using a single mechanical driver.Physics in medicine and biology · 2023Article
- REVIEW ARTICLE Engineering bio-inks for 3D bioprinting cell mechanical microenvironment.International journal of bioprinting · 2023Article
- Assessment of Heterogeneity in Lung Structure and Function During Mechanical Ventilation: A Review of Methodologies.Journal of engineering and science in medical diagnostics and therapy · 2022Review
- Free-breathing MR elastography of the lungs: An in vivo study.Magnetic resonance in medicine · 2022Article
- Updates on Quantitative MRI of Diffuse Liver Disease: A Narrative Review.BioMed research international · 2022Review
- MR elastography: Principles, guidelines, and terminology.Magnetic resonance in medicine · 2021Review
- Soft Microenvironments Induce Chemoresistance by Increasing Autophagy Downstream of Integrin-Linked Kinase.Cancer research · 2020Article
- Acoustic Methods for Pulmonary Diagnosis.IEEE reviews in biomedical engineering · 2019Review
- Matrix biomechanics and dynamics in pulmonary fibrosis.Matrix biology : journal of the International Society for Matrix Biology · 2018Review
- Stiffness reconstruction methods for MR elastography.NMR in biomedicine · 2018Review
- Pancreatic Stiffness Quantified with MR Elastography: Relationship to Postoperative Pancreatic Fistula after Pancreaticoenteric Anastomosis.Radiology · 2018Article
- Article
- Hepatic MR Elastography: Clinical Performance in a Series of 1377 Consecutive Examinations.Radiology · 2016Article
- Experimental and Computational Studies of Sound Transmission in a Branching Airway Network Embedded in a Compliant Viscoelastic Medium.Journal of sound and vibration · 2015Article
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Authors and funding
8 authors.
Funding
Abstract
purposeTo develop a rapid proton MR elastography (MRE) technique that can quantify the absolute shear stiffness of lung parenchyma, to investigate the ability to differentiate respiration-dependent stiffness variations of the lung, and to demonstrate clinical feasibility. MATERIALS AND
methodsA spin-echo echo planar imaging MRE sequence (SE-EPI MRE) with a very short echo time was developed and tested in a series of five healthy volunteers at three different lung volumes: (i) residual volume (RV), (ii) total lung capacity (TLC), (iii) and midway between RV and TLC (MID). At each volume, lung density was quantified using a MR-based density mapping sequence. For reference, data were acquired using the previously described spin-echo lung MRE sequence (SE-MRE). MRE data were also acquired in a patient with proven Idiopathic Pulmonary Fibrosis (IPF) to test clinical feasibility.
resultsThe SE-EPIMRE sequence reduced total acquisition time by a factor of 2 compared with the SE-MRE sequence. Lung parenchyma median shear stiffness for the 5 volunteers quantified with the SE-EPI MRE sequence was 0.9 kPa, 1.1 kPa, and 1.6 kPa at RV, MID, and TLC, respectively. The corresponding values obtained with the SE-MRE sequence were 0.9 kPa, 1.1 kPa, and 1.5 kPa. Absolute shear stiffness was also successfully measured in the IPF patient.
conclusionThe results indicate that stiffness variations due to respiration could be measured with the SE-EPIMRE technique and were equivalent to values generated by the previously described SE-MRE approach. Preliminary data obtained from the patient demonstrate clinical feasibility.
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