ArticleJournal of molecular neuroscience : MN2014
Hyperbaric oxygen treatment produces an antinociceptive response phase and inhibits astrocyte activation and inflammatory response in a rat model of neuropathic pain.
Article in Journal of molecular neuroscience : MN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Hyperbaric Oxygen Therapy in Managing Chronic Pain Syndromes - A Systematic Review.Journal of pain research · 2026Review
- Various gases for the treatment of neuropathic pain: mechanisms, current status, and future perspectives.Medical gas research · 2025Review
- The Role of Astrocytes in Poststroke Rehabilitation.Brain and behavior · 2025Review
- Comparison of the effect of hyperbaric oxygen therapy and tadalafil daily use on erectile function: a prospective, double controlled study.International urology and nephrology · 2024Article
- The Effectiveness of Hyperbaric Oxygen Treatment in Patients with Complex Regional Pain Syndrome: A Retrospective Case series.International journal of medical sciences · 2024Article
- HBO treatment enhances motor function and modulates pain development after sciatic nerve injury via protection the mitochondrial function.Journal of translational medicine · 2023Article
- Hyperbaric Oxygen Therapy in Orthopaedics: An Adjunct Therapy with an Emerging Role.Indian journal of orthopaedics · 2023Review
- Rationale for hyperbaric oxygen therapy in traumatic injury and wound care in small animal veterinary practice.The Journal of small animal practice · 2021Review
- Hyperbaric oxygen treatment in recurrent development of complex regional pain syndrome: A case report.Diving and hyperbaric medicine · 2021Article
- Mechanistic Rationale and Clinical Efficacy of Hyperbaric Oxygen Therapy in Chronic Neuropathic Pain: An Evidence-Based Narrative Review.Pain research & management · 2021Review
- Anti-inflammatory and anti-apoptotic effects of hyperbaric oxygen preconditioning in a rat model of cisplatin-induced peripheral neuropathy.Iranian journal of basic medical sciences · 2020Article
- Hyperbaric oxygen improves functional recovery of rats after spinal cord injury via activating stromal cell-derived factor-1/CXC chemokine receptor 4 axis and promoting brain-derived neurothrophic factor expression.Chinese medical journal · 2019Article
- A single session of hyperbaric oxygen therapy demonstrates acute and long-lasting neuroplasticity effects in humans: a replicated, randomized controlled clinical trial.Journal of pain research · 2019Article
- Hyperbaric oxygen relieves neuropathic pain through AKT/TSC2/mTOR pathway activity to induce autophagy.Journal of pain research · 2019Article
- Early hyperbaric oxygen effects on neuropathic pain and nitric oxide synthase isoforms in CCI rats.Oncotarget · 2018Article
- Neuroprotective effects of hyperbaric oxygen (HBO) therapy on neuronal death induced by sciatic nerve transection in rat.BMC neurology · 2017Article
- The NO-cGMP-PKG signal transduction pathway is involved in the analgesic effect of early hyperbaric oxygen treatment of neuropathic pain.The journal of headache and pain · 2017Article
- Hyperbaric oxygen attenuates neuropathic pain and reverses inflammatory signaling likely via the Kindlin-1/Wnt-10a signaling pathway in the chronic pain injury model in rats.The journal of headache and pain · 2017Article
- Severe medication-induced peripheral neuropathy treated with topical doxepin cream in a paediatric patient with leukaemia.BMJ case reports · 2017Article
- Hyperbaric Oxygen Pretreatment Improves Cognition and Reduces Hippocampal Damage Via p38 Mitogen-Activated Protein Kinase in a Rat Model.Yonsei medical journal · 2017Article
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperbaric oxygen (HBO) treatment has been proven to be a promising candidate for protection of the nervous system after acute injury in animal models of neuropathic pain. The purposes of this study were to examine the antinociceptive response phase induced by HBO treatment in a model of neuropathic pain and to determine the dependence of the treatment's mechanism of alleviating neuropathic pain on the inhibition of spinal astrocyte activation. Neuropathic pain was induced in rats by chronic constriction injury of the sciatic nerve. Mechanical threshold and thermal latency were tested preoperatively and for 1 week postoperatively, four times daily at fixed time points. Methane dicarboxylic aldehyde (MDA) and superoxide dismutase (SOD) parameters were used as indices of oxidative stress response and tested before and after the treatment. The inflammatory cytokines interleukin (IL)-1β and IL-10 were assayed in the sciatic nerve were with enzyme-linked immunoassay. Glial fibrillary acidic protein activation in the spinal cord was evaluated immunohistochemically. The rats exhibited temporary allodynia immediately after HBO treatment completion. This transient allodynia was closely associated with changes in MDA and SOD levels. A single HBO treatment caused a short-acting antinociceptive response phase. Repetitive HBO treatment led to a long-acting antinociceptive response phase and inhibited astrocyte activation. These results indicated that HBO treatment played a dual role in the aggravation and alleviation of neuropathic pain, though the aggravated pain effect (transient allodynia) was far less pronounced than the antinociceptive phase. Astrocyte inhibition and anti-inflammation may contribute to the antinociceptive effect of HBO treatment after nerve injury.
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