ArticleJournal of molecular neuroscience : MN2014
Overexpression of MAP-2 via formation of microtubules plays an important role in the sprouting of mossy fibers in epileptic rats.
Article in Journal of molecular neuroscience : MN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Non-thermal plasma directly accelerates neuronal proliferation by stimulating axon formation.Scientific reports · 2022Article
- Microtubule Dynamics and Neuronal Excitability: Advances on Cytoskeletal Components Implicated in Epileptic Phenomena.Cellular and molecular neurobiology · 2022Review
- Therapeutic potential of pregnenolone and pregnenolone methyl ether on depressive and CDKL5 deficiency disorders: Focus on microtubule targeting.Journal of neuroendocrinology · 2022Review
- Non-thermal plasma application enhances the recovery of transected sciatic nerves in rats.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale.Frontiers in neurology · 2021Review
- The study of microtubule dynamics and stability at the postsynaptic density in a rat pilocarpine model of temporal lobe epilepsy.Annals of translational medicine · 2020Article
- Serum Visinin-Like Protein 1 Is a Better Biomarker Than Neuron-Specific Enolase for Seizure-Induced Neuronal Injury: A Prospective and Observational Study.Frontiers in neurology · 2020Article
- ReMAPping the microtubule landscape: How phosphorylation dictates the activities of microtubule-associated proteins.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- Echinoderm microtubule-associated protein -like protein 5 in anterior temporal neocortex of patients with intractable epilepsy.Iranian journal of basic medical sciences · 2015Article
- Functionalized α-Helical Peptide Hydrogels for Neural Tissue Engineering.ACS biomaterials science & engineering · 2015Article
- Effect of connexin 36 blockers on the neuronal cytoskeleton and synaptic plasticity in kainic acid-kindled rats.Translational neuroscience · 2015Article
- HAEC in the treatment of brain hemorrhage: a preliminary observation in rabbits.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to investigate the changes of microtubule-associated protein 2 (MAP-2) in epileptic dentate gyrus and significance in epilepsy. Alterations in MAP-2 immunoreactivity (MAP2-IR) in kindling model of epilepsy were investigated in rats with survival times ranging from 3 to 30 days. Nissl staining and electron microscopic studies were used to explore more deeply. Electron microscopic was employed to detect tubulin formation and assembly. Immunohistochemical assay was used to examine co-localization of tubulin and MMP-2. Results indicated that MAP2-IR obviously enhanced in dendrites of granule cells 3 days after kindling and remained enhanced up to 14 days (P < 0.01). It returned to control patterns 20 to 30 days after kindling (P < 0.01). Nissl staining demonstrated a negative correlation between enhancement of MAP-2 and degeneration of hilar neurons (r = -0.9274). Electron microscopic studies showed that microtubules of dendrite in dentate molecular increased 3 days after kindling and obviously increased 14 days after kindling (P < 0.05). Tubulin protein showed a well co-localization with MMP-2 protein. Treatment of paclitaxel significantly decreased tubulin formation and assembly compared with untreated group (P < 0.01). Sprouting of dentate granule cell axons and synaptic contacts between nerve terminal and dendrite were discovered. Overexpression of MAP-2 via formation of microtubules plays an important role in the sprouting of mossy fibers in epileptic rats.
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