Trial reportJournal of cancer survivorship : research and practice2014
Influence of weight training on skeletal health of breast cancer survivors with or at risk for breast cancer-related lymphedema.
Trial report in Journal of cancer survivorship : research and practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 7 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Effect of exercise on bone-related outcomes in patients with cancer affected by bone metastases or bone loss: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Pooled it
- The effects of exercise on the bone health of people with cancer: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Pooled it
- Resistance Training in Breast Cancer Survivors: A Systematic Review of Exercise Programs.International journal of environmental research and public health · 2020Pooled it
- The effect of exercise on bone mineral density in adult cancer survivors: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Pooled it
- Physical activity for women with breast cancer after adjuvant therapy.The Cochrane database of systematic reviews · 2018Pooled it
- Exercise for improving bone health in women treated for stages I-III breast cancer: a systematic review and meta-analyses.Journal of cancer survivorship : research and practice · 2017Pooled it
- Non-pharmacological interventions for cognitive impairment due to systemic cancer treatment.The Cochrane database of systematic reviews · 2016Pooled it
- A randomized study to prevent lymphedema in women treated for breast cancer: CALGB 70305 (Alliance).Cancer · 2021Trial
- Trial
- Trial
- A hybrid effectiveness-implementation trial of an evidence-based exercise intervention for breast cancer survivors.Journal of the National Cancer Institute. Monographs · 2014Trial
- Exercise and Bone Health in Cancer: Enemy or Ally?Cancers · 2022Review
- Resistance Exercise for Breast Cancer Patients? Evidence from the Last Decade.Breast care (Basel, Switzerland) · 2021Review
- Five-year follow-up results of aerobic and impact training on bone mineral density in early breast cancer patients.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Body Composition, Metabolism, and Inflammation in Breast Cancer Survivors and Healthy Age-matched Controls: A Cross-Sectional Analysis.International journal of exercise science · 2020Article
- The legacy of lymphedema: Impact on nursing practice and vascular access.Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2019Article
- Weight management and physical activity throughout the cancer care continuum.CA: a cancer journal for clinicians · 2018Review
- A Scientific Rationale to Improve Resistance Training Prescription in Exercise Oncology.Sports medicine (Auckland, N.Z.) · 2017Article
- AACR Cancer Progress Report 2015.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
purposeThis study aimed to determine whether the Physical Activity and Lymphedema (PAL) trial weight training program for breast cancer survivors at risk of or with breast cancer-related lymphedema provided skeletal benefits.
methodsOf the 295 participants in the randomized controlled PAL trial, 258 (weight training; N = 128; control, N = 130) had complete measures of bone mineral density (BMD (in grams per square centimeter)) of the proximal femur and lumbar spine and were also categorized by T scores. Women in the weight training group performed slowly progressive weight training 2 days/week for 12 months compared to women in the control group who maintained their usual physical activities.
resultsThere were no significant differences in the rate of BMD change at any skeletal site between weight training and control groups, regardless of menopausal status. Distribution of bone health categories was not significantly different between groups at baseline, but became different at 12 months (p < 0.03) among postmenopausal women due to an increase in the percentage of controls who became osteopenic (35 to 44%) compared to stable bone health in weight lifters.
conclusionsThe PAL weight training program that increased muscle strength without exacerbating or causing lymphedema among breast cancer survivors was not as efficacious at improving skeletal health. The skeletal loads produced from the PAL program may be insufficient to notably shift BMD, but may have a subtle osteogenic effect. IMPLICATIONS FOR CANCER SURVIVORS: The safety and efficacy of rigorous weight training programs for improving skeletal health in women at risk for or with breast cancer-related lymphedema remain to be determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.