ArticleMagnetic resonance in medicine2014
Maximizing T2-exchange in Dy(3+)DOTA-(amide)X chelates: fine-tuning the water molecule exchange rate for enhanced T2 contrast in MRI.
Article in Magnetic resonance in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- LnDOTA puppeteering: removing the water molecule and imposing tetragonal symmetry.Chemical science · 2023Article
- Magnetic Anisotropy Trends along a Full 4f-Series: TheJournal of the American Chemical Society · 2021Article
- A Frequency-Selective pH-Responsive paraCEST Agent.Angewandte Chemie (International ed. in English) · 2020Article
- Binding site exchange kinetics revealed through efficient spin-spin dephasing of hyperpolarizedChemical science · 2020Article
- Covalency and magnetic anisotropy in lanthanide single molecule magnets: the DyDOTA archetype.Chemical science · 2019Article
- Two decades of dendrimers as versatile MRI agents: a tale with and without metals.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2018Review
- Lanthanide-Based TAngewandte Chemie (International ed. in English) · 2017Article
- Article
- A biomarker-responsive TMagnetic resonance in medicine · 2017Article
- Advances in Magnetic Resonance Imaging Contrast Agents for Biomarker Detection.Annual review of analytical chemistry (Palo Alto, Calif.) · 2016Review
- Basic MR relaxation mechanisms and contrast agent design.Journal of magnetic resonance imaging : JMRI · 2015Review
- A pH-Responsive MRI Agent that Can Be Activated Beyond the Tissue Magnetization Transfer Window.Angewandte Chemie (International ed. in English) · 2015Article
- Molecular engineering of nonmetallic biosensors for CEST MRI.ACS chemical biology · 2015Article
- Double agents and secret agents: the emerging fields of exogenous chemical exchange saturation transfer and TResearch and reports in nuclear medicine · 2015Article
- Natural D-glucose as a biodegradable MRI relaxation agent.Magnetic resonance in medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
purposeThe water molecule exchange rates in a series of DyDOTA-(amide)X chelates were fine-tuned to maximize the effects of T2-exchange line broadening and improve T2 contrast.
methodsFour DyDOTA-(amide)X chelates having a variable number of glycinate side-arms were prepared and characterized as T2-exchange agents. The nonexchanging DyTETA chelate was also used to measure the bulk water T2 reduction due solely to T2*. The total transverse relaxivity (r2tot) at 22, 37, and 52°C for each chelate was measured in vitro at 9.4 Tesla (400 MHz) by fitting plots of total T2 (-1) versus concentration. The water molecule exchange rates for each complex were measured by fitting (17)O line-width versus temperature data taken at 9.4 Tesla (54.3 MHz).
resultsThe measured transverse relaxivities due to water molecule exchange (r2ex) and bound water lifetimes (τM) were in excellent agreement with Swift-Connick theory, with DyDOTA-(gly)3 giving the largest r2ex = 11.8 s(-1) mM(-1) at 37°C.
conclusionBy fine-tuning the water molecule exchange rate at 37°C, the transverse relaxivity has been increased by 2 to 30 times compared with previously studied Dy(3+)-based chelates. Polymerization or dendrimerization of the optimal chelate could yield a highly sensitive, molecule-sized T2 contrast agent for improved molecular imaging applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.