ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2014
Effects of plant extracts on the reversal of glucose-induced impairment of stress-resistance in Caenorhabditis elegans.
Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Paeoniflorin mitigates high glucose-induced lifespan reduction by inhibiting insulin signaling inFrontiers in pharmacology · 2023Article
- The role of anthocyanins as antidiabetic agents: from molecular mechanisms to in vivo and human studies.Journal of physiology and biochemistry · 2021Review
- Hibiscus sabdariffa L. extract prolongs lifespan and protects against amyloid-β toxicity in Caenorhabditis elegans: involvement of the FoxO and Nrf2 orthologues DAF-16 and SKN-1.European journal of nutrition · 2020Article
- Polyphenols and Metabolites Enhance Survival in Rodents and Nematodes-Impact of Mitochondria.Nutrients · 2019Article
- Mitochondrial Oxidative Stress Impairs Energy Metabolism and Reduces Stress Resistance and Longevity ofOxidative medicine and cellular longevity · 2019Article
- Article
- 18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures.Antioxidants & redox signaling · 2016Article
- Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative Agents.Molecules (Basel, Switzerland) · 2016Article
- Hibiscus rosa sinensis Linn. Petals Modulates Glycogen Metabolism and Glucose Homeostasis Signalling Pathway in Streptozotocin-Induced Experimental Diabetes.Plant foods for human nutrition (Dordrecht, Netherlands) · 2016Article
- Article
- The lifespan-extending effects of Nymphaea hybrid root extract in the nematode Caenorhabditis elegans.Plant foods for human nutrition (Dordrecht, Netherlands) · 2014Article
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Authors and funding
7 authors.
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Abstract
Enhanced blood glucose levels are a hallmark of diabetes and are associated with diabetic complications and a reduction of lifespan. In order to search for plant extracts that display preventive activities in such a scenario, we tested 16 extracts used in human nutrition for their survival enhancing activities in the nematode Caenorhabditis elegans. Nematodes were exposed for 48 h to 10 mM glucose in the absence or presence of 0.1% extract. Thereafter, survival was measured at 37 °C. Extracts made from coffee, kola, rooibos and cinnamon, did not influence the glucose-induced reduction of survival. Those made from ginseng, camomile, lime blossom, paraguay tea, balm, rhodiola, black tea, or knotgrass all extended the lifespan of the glucose-treated nematodes significantly but did not rescue survival completely. Extracts from the leaves of blackberries, from hibiscus, elderberries, or jiaogulan completely countered the glucose-induced survival reduction. A potent activation of the proteasome was shown for the most preventive extracts suggesting a more efficient degradation of proteins impaired by glucose. In conclusion, we present a simple animal model to screen for plant extracts with potency to reverse glucose toxicity. Extracts from blackberry leaves, hibiscus, elderberries, and jiaogulan were identified as very potent in this regard whose exact mechanisms of action appear worthwile to investigate at the molecular level.
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