ArticleJournal of assisted reproduction and genetics2014
Embryo quality but not pronuclear score is associated with clinical pregnancy following IVF.
Article in Journal of assisted reproduction and genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Effect of the Peiyu granules on early miscarriage among women undergoing embryo transfer: a randomized, double-blind, placebo-controlled trial.Frontiers in endocrinology · 2025Trial
- Effects of cumulus cell removal time during in vitro fertilization on embryo quality and pregnancy outcomes: a prospective randomized sibling-oocyte study.Reproductive biology and endocrinology : RB&E · 2016Trial
- Time-series clustering of the migration speed of nucleolus-precursor bodies in human zygotes and live birth following assisted reproductive technology.Journal of assisted reproduction and genetics · 2025Article
- In Vitro Fertilisation and Intracytoplasmic Sperm Injection predictive factors: A review of the effect of female age, ovarian reserve, male age, and male factor on IVF/ICSI treatment outcomes.JBRA assisted reproduction · 2023Review
- It is not worth postponing frozen embryo transfers after oocyte pickup: A retrospective cohort study based on propensity score matching.Frontiers in endocrinology · 2022Article
- Factors Influencing Success Rate of Intracytoplasmic Sperm Injection with Azoospermic Male Patients.Geburtshilfe und Frauenheilkunde · 2020Article
- An artificial neural network for the prediction of assisted reproduction outcome.Journal of assisted reproduction and genetics · 2019Article
- Prediction of the in vitro developmental competence of early-cleavage-stage human embryos with time-lapse imaging and oxygen consumption rate measurement.Reproductive medicine and biology · 2018Article
- Determinants of The Grade A Embryos in Infertile Women; Zero-Inflated Regression Model.Cell journal · 2017Article
- Prediction of blastocyst development and implantation potential in utero based on the third cleavage and compaction times in mouse pre-implantation embryos.The Journal of reproduction and development · 2017Article
- Article
- Non-invasive methods for embryo selection.Facts, views & vision in ObGyn · 2016Review
- The effect of serum and follicular fluid amyloid-associated protein levels on in vitro fertilization outcome in patients with polycystic ovary syndrome.Journal of assisted reproduction and genetics · 2015Article
- Endometrial pattern, but not endometrial thickness, affects implantation rates in euploid embryo transfers.Fertility and sterility · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe association between pronuclear (PN) scoring of embryos from assisted reproductive technology (ART) and clinical pregnancy remains controversial. We hypothesized that embryos with PNs scored on the day of fertilization check offer better embryo selection on day 3 and higher CPR compared to non-PN scored embryos.
methodsPatients (19-46 years) undergoing IVF/ICSI cycles at Montefiore's Institute for Reproductive Medicine and Health between January 2006 and December 2009 were included in our study. We analyzed fresh day 3 cycles only with autologous oocytes and partner's fresh sperm (n = 344). A total of 1,899 embryos were included. We compared CPR from non-PN scored embryos (Group 1, n = 835) with PN scored embryos (Group 2, n = 1,064). Composite scores by patient were developed based on embryo disposition. We also assessed traditional embryo grading derived from cell number, fragmentation and cell symmetry. Data analysis included chi square and t test to determine if PN scoring was associated with improved CPR, and to compare the additional variables.
resultsCPR between Group 1 and Group 2 were not different (p = 0.91). CPR was significantly associated with female age, number of mature oocytes retrieved, number of day 3 embryos and grade of embryos transferred on day 3 (p < 0.05).
conclusionPN scoring was not associated with improved CPR in day 3 embryo transfers. Mean grade of transferred embryos continues to be a well-established, independent predictor of CPR. We conclude that further refinement of embryo grading by PN scoring is not beneficial.
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