ArticleCurrent HIV/AIDS reports2014
Are infants unique in their ability to be "functionally cured" of HIV-1?
Article in Current HIV/AIDS reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Studies of young adults with perinatal HIV infection provide new clues for HIV cure.AIDS (London, England) · 2025Article
- Early antiretroviral treatment of infants to attain HIV remission.EClinicalMedicine · 2020Article
- Recovery of effective HIV-specific CD4+ T-cell activity following antiretroviral therapy in paediatric infection requires sustained suppression of viraemia.AIDS (London, England) · 2018Article
- Age at antiretroviral therapy initiation and cell-associated HIV-1 DNA levels in HIV-1-infected children.PloS one · 2018Article
- The pharmacological treatment of acute HIV infections in neonates.Expert review of clinical pharmacology · 2017Review
- Immune activation and paediatric HIV-1 disease outcome.Current opinion in HIV and AIDS · 2016Review
- Young age at start of antiretroviral therapy and negative HIV antibody results in HIV-infected children when suppressed.AIDS (London, England) · 2015Article
- Cell-to-cell contact facilitates HIV transmission from lymphocytes to astrocytes via CXCR4.AIDS (London, England) · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The recent report of an infant that appears to have achieved a "functional cure" of HIV-1 following receipt of antiretroviral therapy (ART) within 30 hours of birth raises many questions: was the child infected? Was this result due to unique features of this particular infant's immune system, the immune system of infants or the very early initiation of effective ART? In this manuscript, we discuss the pathogenesis of HIV-1 in infants, highlighting the unique features of infant immune development and how these may inform efforts to cure HIV infection. We will also compare the path to infant "cure" to cures in adults.
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Identifiers
24390641What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.