ArticleJournal of autism and developmental disorders2014
Why autism must be taken apart.
Article in Journal of autism and developmental disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Multimodal evidence and technology-enabled accommodations for autistic adults: an evidential framework for autism research and practice.Frontiers in psychiatry · 2026Article
- Should We Continue to Tell Autistic People that Their Brains are Different?Psychological reports · 2025Review
- The world is nuanced but pixelated: Autistic individuals' perspective on HIPPEA.Autism : the international journal of research and practice · 2024Article
- Autism severity and its relationship to disability.Autism research : official journal of the International Society for Autism Research · 2023Article
- Does the current state of biomarker discovery in autism reflect the limits of reductionism in precision medicine? Suggestions for an integrative approach that considers dynamic mechanisms between brain, body, and the social environment.Frontiers in psychiatry · 2023Article
- Re-Examining Labels in Neurocognitive Research: Evidence from Bilingualism and Autism as Spectrum-Trait Cases.Brain sciences · 2022Review
- Exploring Change in Children's and Art Therapists' Behavior during 'Images of Self', an Art Therapy Program for Children Diagnosed with Autism Spectrum Disorders: A Repeated Case Study Design.Children (Basel, Switzerland) · 2022Article
- Insights from losing the autism diagnosis: Autism spectrum disorder as a biological entity.Frontiers in psychiatry · 2022Article
- Rethinking Our Concepts and Assumptions About Autism.Frontiers in psychiatry · 2022Article
- ASD-Time for a paradigm shift.Frontiers in psychiatry · 2022Article
- Prototyping as subtyping strategy for studying heterogeneity in autism.Autism research : official journal of the International Society for Autism Research · 2021Article
- Drug development for Autism Spectrum Disorder (ASD): Progress, challenges, and future directions.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2021Review
- Going Beyond the Catch-22 of Autism Diagnosis and Research. The Moral Implications of (Not) Asking "What Is Autism?"Frontiers in psychology · 2020Article
- Parsing Heterogeneity in Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder with Individual Connectome Mapping.Brain connectivity · 2019Article
- Big data approaches to decomposing heterogeneity across the autism spectrum.Molecular psychiatry · 2019Review
- ASD Comorbidity in Fragile X Syndrome: Symptom Profile and Predictors of Symptom Severity in Adolescent and Young Adult Males.Journal of autism and developmental disorders · 2019Article
- Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development.Autism : the international journal of research and practice · 2019Article
- Brain Connectivity and Neuroimaging of Social Networks in Autism.Trends in cognitive sciences · 2018Review
- Autism: a transdiagnostic, dimensional, construct of reasoning?The European journal of neuroscience · 2018Review
- Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development.Journal of autism and developmental disorders · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although accumulated evidence has demonstrated that autism is found with many varied brain dysfunctions, researchers have tried to find a single brain dysfunction that would provide neurobiological validity for autism. However, unitary models of autism brain dysfunction have not adequately addressed conflicting evidence, and efforts to find a single unifying brain dysfunction have led the field away from research to explore individual variation and micro-subgroups. Autism must be taken apart in order to find neurobiological treatment targets. Three research changes are needed. The belief that there is a single defining autism spectrum disorder brain dysfunction must be relinquished. The noise caused by the thorny brain-symptom inference problem must be reduced. Researchers must explore individual variation in brain measures within autism.
Indexed as
Identifiers
24390538What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.