ReviewJournal of neural transmission (Vienna, Austria : 1996)2015
Mechanisms underlying the neuroprotective effect of brain reserve against late life depression.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Effects of physical activity and exercise on the cognitive function of patients with Alzheimer disease: a meta-analysis.BMC geriatrics · 2019Pooled it
- The effect of digital reminiscence therapy on people with dementia: a pilot randomized controlled trial.BMC geriatrics · 2020Trial
- Effects of transcranial random noise stimulation combined with Graded Repetitive Arm Supplementary Program (GRASP) on motor rehabilitation of the upper limb in sub-acute ischemic stroke patients: a randomized pilot study.Journal of neural transmission (Vienna, Austria : 1996) · 2019Trial
- Therapeutic Use and Chronic Abuse of CNS Stimulants and Anabolic Drugs.Current issues in molecular biology · 2022Review
- Health lifestyles and Chinese oldest-old's subjective well-being-evidence from a latent class analysis.BMC geriatrics · 2021Article
- Moderate-Intensity Physical Activity, Music and Art Activities Preserved Cognitive Health in Older Adults: An Argument for Social Prescribing Solution.Frontiers in aging neuroscience · 2021Article
- Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Alteration of the Intra- and Inter-Lobe Connectivity of the Brain Structural Network in Normal Aging.Entropy (Basel, Switzerland) · 2020Article
- Moderation-Mediation Effects in Bilingualism and Cognitive Reserve.Frontiers in psychology · 2020Review
- Cognitive Reserve Moderates Effects of White Matter Hyperintensity on Depressive Symptoms and Cognitive Function in Late-Life Depression.Frontiers in psychiatry · 2020Article
- Effects of age and cognitive function on data quality of standardized surveys in nursing home populations.BMC geriatrics · 2019Article
- Modifiable Risk Factors Discriminate Memory Trajectories in Non-Demented Aging: Precision Factors and Targets for Promoting Healthier Brain Aging and Preventing Dementia.Journal of Alzheimer's disease : JAD · 2019Article
- Effects of Cognitive Reserve on Cognitive Performance in a Follow-Up Study in Older Adults With Subjective Cognitive Complaints. The Role of Working Memory.Frontiers in aging neuroscience · 2018Article
- Enhancement of Visuospatial Working Memory by the Differential Outcomes Procedure in Mild Cognitive Impairment and Alzheimer's Disease.Frontiers in aging neuroscience · 2018Article
- Aberrant Default Mode Network Underlying the Cognitive Deficits in the Patients With Late-Onset Depression.Frontiers in aging neuroscience · 2018Review
- Performance Level and Cortical Atrophy Modulate the Neural Response to Increasing Working Memory Load in Younger and Older Adults.Frontiers in aging neuroscience · 2018Article
- Sustained Effects of Memory and Lifestyle Interventions on Memory Functioning of Older Adults: An 18-Month Follow-Up Study.Frontiers in aging neuroscience · 2018Article
- Gray Matter Volume and Cognitive Performance During Normal Aging. A Voxel-Based Morphometry Study.Frontiers in aging neuroscience · 2018Article
- Impact of Aging on the Auditory System and Related Cognitive Functions: A Narrative Review.Frontiers in neuroscience · 2018Review
- Low plasma tryptophan is associated with olfactory function in healthy elderly community dwellers in Japan.BMC geriatrics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression is common and medically relevant illness that has been associated to a state of "accelerated aging" and can significantly compromise successful aging. In recent years, the concept of "brain reserve" has emerged to describe some individuals having an increased "baseline adaptive neuroplasticity", providing greater dynamic capacity for adjusting and remodeling cortical circuits to various stressors. We hypothesize that brain reserve may have neuroprotective effects against late life depression. Here, we discuss the modulatory capacity of stress and corticosteroid hormones on hippocampal plasticity and neuronal viability in late life depression as well as the anti-depressive of ketamine and scopolamine mediated by stimulation of the mammalian target of rapamycin, increased inhibitory phosphorylation of GSK-3β, and increased synaptogenesis. This review shall shed light on complex neurobiological mechanisms that underpin late life depression and help to better understand neural correlates of resilience. Investigating how rat models of increased cognitive reserve mitigate a chronic mild stress-elicited depression will afford new insights in the search for new therapeutic targets to treat this neuropsychiatric disorder.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.