ArticleOral health and dental management2013
Cariogenicity of Streptococcus mutans glucan-binding protein deletion mutants.
Article in Oral health and dental management, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 42 citations in OpenAlex.
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- The Dentin Microbiome: A Metatranscriptomic Evaluation of Caries-Associated Bacteria.Biomedicines · 2025Article
- Polymer vesicles for the delivery of inhibitors of cariogenic biofilm.Dental materials : official publication of the Academy of Dental Materials · 2024Article
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- Sugar Substitute Stevia Inhibits Biofilm Formation, Exopolysaccharide Production, and Downregulates the Expression of Streptococcal Genes Involved in Exopolysaccharide Synthesis.Dentistry journal · 2023Article
- Antibacterial Effect of Miswak herbal toothpaste Compared to Fluoride Toothpaste in High Caries Risk Patients: Randomized Clinical Trial.Journal of clinical and experimental dentistry · 2023Article
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- Hydrogel-Encapsulated Biofilm Inhibitors Abrogate the Cariogenic Activity ofJournal of medicinal chemistry · 2023Article
- Association of polymicrobial interactions with dental caries development and prevention.Frontiers in microbiology · 2023Review
- Discovery of Novel Iminosugar Compounds Produced byMicrobiology spectrum · 2022Article
- Effect of curcumin-encapsulated PluronicLasers in medical science · 2022Article
- The application of selenium nanoparticles for enhancing the efficacy of photodynamic inactivation of planktonic communities and the biofilm of Streptococcus mutans.BMC research notes · 2022Article
- Unraveling the binding microprocess of individualJournal of oral microbiology · 2022Article
- Review
- Ferumoxytol Nanoparticles Target Biofilms Causing Tooth Decay in the Human Mouth.Nano letters · 2021Article
- Precision targeting of bacterial pathogen via bi-functional nanozyme activated by biofilm microenvironment.Biomaterials · 2021Article
- Antibodies generated against dextransucrase exhibit potential anticariostatic properties in Streptococcus mutans.Applied microbiology and biotechnology · 2020Article
- Polymer Adhesin Domains in Gram-Positive Cell Surface Proteins.Frontiers in microbiology · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Streptococcus mutans is a principal etiologic agent in the development of dental caries due to its exceptional aciduric and acidogenic properties, and its ability to adhere and accumulate in large numbers on tooth surfaces in the presence of sucrose. Sucrose-dependent adherence is mediated by glucans, polymers of glucose synthesized from sucrose by glucosyltransferase (Gtf) enzymes. S. mutans makes several proteins that have the property of binding glucans. We hypothesized that three of these glucan-binding proteins (Gbps), Gbps A, C and D, contribute to the cariogenicity of S. mutans. A specific pathogen-free rat model was used to compare the cariogenicity of S. mutans UA130 and a panel of mutants with individual or multiple gbp gene deletions. The mutants were also evaluated in vitro for properties related to cariogenicity, such as acidogenicity, aciduricity, and adhesion to glucan. Only a subset of Gbp mutants were attenuated for cariogenicity, with the combined loss of Gbps A and C most affecting smooth surface caries. The attenuation of Gbp mutant strains was unlikely due to differences in acid-related properties since the mutants were at least as acidogenic and acid-tolerant as the parental strain. Additionally, loss of Gbps did not reduce adhesion to a pre-formed biofilm of S. sanguinis. Analyses of the caries data with in vitro biofilm properties previously determined for the mutant panel found correlations between cariogenicity and biofilm depth and substratum coverage. It is concluded that Gbps contribute to the cariogenicity of S. mutans through a mechanism that may involve alteration of biofilm architecture.
Identifiers
24390015PMC4437697W2310161533What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.