ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2015
Assessment of essential characteristics of two different scaffolds for tendon in situ regeneration.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 15 citations in OpenAlex.
- The Role of Collagen-Based Biomaterials in Chronic Wound Healing and Sports Medicine Applications.Bioengineering (Basel, Switzerland) · 2021Review
- Regenerative Engineering of the Rotator Cuff of the Shoulder.ACS biomaterials science & engineering · 2018Article
- Tenogenic modulating insider factor: Systematic assessment on the functions of tenomodulin gene.Gene · 2016Review
- Ginsenoside Rg1 and platelet-rich fibrin enhance human breast adipose-derived stem cell function for soft tissue regeneration.Oncotarget · 2016Article
- The long head of the biceps tendon is a suitable cell source for tendon tissue regeneration.Archives of medical science : AMS · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRotator cuff tears are challenging as the rate of re-ruptures remains high. Thus, new therapeutic strategies need to be developed. Tendon in situ regeneration (TSR) attempts to produce cell-scaffold constructs in vitro, which can produce tendinous tissue of high quality after replantation. Therefore, it is essential to find suitable scaffolds that can provide acceptable biofunctionality and biocompatibility. This study compares characteristics of scaffolds for in situ regeneration: a polyglycolic acid/PDS scaffold (PP-sca) (Ethisorb, Ethicon, Germany) and a collagen sponge (col-spo) (TissueTek, Germany) with a basal strengthening membrane.
methodsTendon-derived cells (TDCs) were isolated from the long head of the biceps tendon. Gene expression for collagen type I, collagen type III, decorin, scleraxis and tenomodulin was analysed in the third cell passage. Cell proliferation in cell seeded scaffolds was tested using a WST-1 assay. In addition, the tensile strength of both scaffolds was measured using a universal-testing machine (Zwick/Roell, Ulm, Germany).
resultsThe results from this study indicate a genotypic drift during the in vitro cultivation of the TDCs. The PP-sca showed good biofunctional results, including low initial loss of cells after cell seeding. The proliferation rates were approximately equal in each type of scaffold. The col-spo provided superior tensile strength compared with the PP-sca (p < 0.01).
conclusionOverall, the col-spo seems to be more suitable for TSR. It may become a clinical alternative in the future to achieve more satisfying results, concerning function and pain. LEVEL OF EVIDENCE: Experimental study/case series, Level IV.
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