Evidence map›Paper›PMID 24389870›Full record

ArticleScientific reports2014

More than apples and oranges--detecting cancer with a fruit fly's antenna.

Martin Strauch, Alja Lüdke, Daniel Münch, Thomas Laudes, C Giovanni Galizia, Eugenio Martinelli, Luca Lavra, Roberto Paolesse, Alessandra Ulivieri, Alexandro Catini and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 88 citations in OpenAlex.

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  9. Intracellular Trafficking of Size-Tuned Nanoparticles for Drug Delivery.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Martin Strauch1] Neurobiology, University of Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany [2].
Alja Lüdke1] Neurobiology, University of Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany [2].
Daniel Münch1] Neurobiology, University of Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany [2].
Thomas LaudesNeurobiology, University of Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany.
C Giovanni Galizia1] Neurobiology, University of Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany [2] Department of Electronic Engineering, University of Rome Tor Vergata, Via del Politecnico 1, 00133 Roma, Italy.
Eugenio MartinelliDepartment of Electronic Engineering, University of Rome Tor Vergata, Via del Politecnico 1, 00133 Roma, Italy.
Luca LavraDepartment of Clinical and Molecular Medicine, University of Rome La Sapienza, Via di Grottarossa 1035, 00189 Roma, Italy.
Roberto PaolesseDepartment of Chemistry, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Roma, Italy.
Alessandra UlivieriDepartment of Electronic Engineering, University of Rome Tor Vergata, Via del Politecnico 1, 00133 Roma, Italy.
Alexandro CatiniDepartment of Electronic Engineering, University of Rome Tor Vergata, Via del Politecnico 1, 00133 Roma, Italy.
Rosamaria CapuanoDepartment of Electronic Engineering, University of Rome Tor Vergata, Via del Politecnico 1, 00133 Roma, Italy.
Corrado Di NataleDepartment of Electronic Engineering, University of Rome Tor Vergata, Via del Politecnico 1, 00133 Roma, Italy.
University of Rome Tor Vergata · ITUniversity of Konstanz · DESapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer cells and non-cancer cells differ in their metabolism and they emit distinct volatile compound profiles, allowing to recognise cancer cells by their scent. Insect odorant receptors are excellent chemosensors with high sensitivity and a broad receptive range unmatched by current gas sensors. We thus investigated the potential of utilising the fruit fly's olfactory system to detect cancer cells. Using in vivo calcium imaging, we recorded an array of olfactory receptor neurons on the fruit fly's antenna. We performed multidimensional analysis of antenna responses, finding that cell volatiles from different cell types lead to characteristic response vectors. The distances between these response vectors are conserved across flies and can be used to discriminate healthy mammary epithelial cells from different types of breast cancer cells. This may expand the repertoire of clinical diagnostics, and it is the first step towards electronic noses equipped with biological sensors, integrating artificial and biological olfaction.

Indexed as

AnimalsArthropod AntennaeDrosophila melanogasterHumansNeoplasmsOdorantsOlfactory Receptor NeuronsVolatile Organic CompoundsVolatile Organic Compounds

Identifiers

PMID24389870
PMCPMC3880960
OpenAlexW2133525260

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.