ArticleThe American journal of pathology1987
Choroid plexus tumors. An immunocytochemical study with particular reference to the coexpression of intermediate filament proteins.
Article in The American journal of pathology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 91 citations in OpenAlex.
- The composition of choroid plexus tumor research: a bibliometric analysis of the 100 most impactful studies to date.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Primary choroid plexus papilloma of the sellar region.Journal of neuro-oncology · 2008Article
- Choroid plexus papillomas: consideration of a surgical series of 33 cases.Acta neurochirurgica · 1996Article
- The prevalence of BCL-2 immunoreactivity in breast carcinomas and its clinicopathological correlates, with particular reference to oestrogen receptor status.Virchows Archiv : an international journal of pathology · 1994Article
- Gastric giardiasis.Journal of clinical pathology · 1992Article
- Intermediate filament protein expression and mesoderm formation in the rabbit embryo : A double-labelling immunofluorescence study.Roux's archives of developmental biology : the official organ of the EDBO · 1992Article
- Malignant rhabdoid tumour of the uterus: an immunohistochemical and ultrastructural study.Virchows Archiv. A, Pathological anatomy and histopathology · 1992Article
- Unexpected immunoreactivities of intermediate filament antibodies in human brain and brain tumors.The American journal of pathology · 1991Article
- Comprehensive lectin histochemistry of normal and neoplastic human choroid plexus cells: alternation of lectin-binding patterns through neoplastic transformation.Acta neuropathologica · 1991Article
- Glial fibrillary acidic protein immunoreactivity in normal and diseased human breast.Virchows Archiv. A, Pathological anatomy and histopathology · 1991Article
- Immunocytochemical localization of progesterone receptors in endocrine cells of the human pancreas.The American journal of pathology · 1990Article
- Coexpression patterns of vimentin and glial filament protein with cytokeratins in the normal, hyperplastic, and neoplastic breast.The American journal of pathology · 1990Article
- A marker for primary choroid plexus neoplasms.The American journal of pathology · 1990Article
- Cytokeratin-immunoreactive cells of human lymph nodes and spleen in normal and pathological conditions. An immunocytochemical study.Virchows Archiv. A, Pathological anatomy and histopathology · 1990Article
- Clinicopathologic correlations in epithelial choroid plexus neoplasms: a study of 52 cases.Acta neuropathologica · 1990Article
- Immunohistochemical study of ependymal neoplasms: histological subtypes and glial and epithelial characteristics.Virchows Archiv. A, Pathological anatomy and histopathology · 1990Article
- Distribution of epithelial membrane antigen in normal and neoplastic human ependyma.Acta neuropathologica · 1989Article
- Immunohistochemical study of cells positive for glial fibrillary acidic protein (GFAP) in the human pituitary gland, with special reference to folliculo-stellate cells.Histochemistry · 1989Article
- Subarachnoid epithelial cyst of the cerebellum. Immunohistochemical and ultrastructural studies.Acta neuropathologica · 1989Article
- Immunocytochemical localization of vimentin in stellate cells (folliculo-stellate cells) of the rat, cat and rabbit pituitary pars distalis.Anatomy and embryology · 1989Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sixteen choroid plexus tumors (CPTs) have been investigated for the localization of different immunocytochemical markers of epithelial and nonepithelial nature, namely, simple epithelial-type cytokeratins, vimentin, glial fibrillary acidic protein (GFAP), a panepithelial antigen defined by the lu-5 monoclonal antibody (lu-5 antigen), S-100 protein, and epithelial membrane antigen (EMA). Intermediate filament proteins have been identified in paraffin sections of 14 of 16 cases (87.5%). In all these tumors, cytokeratins and vimentin were constantly coexpressed by the neoplastic cells, in a manner similar to that of the cells lining normal choroid plexus. In 7 of these 14 cases, in addition to cytokeratins and vimentin, the neoplastic cells were shown to coexpress GFAP, which is not synthesized by their normal cell counterpart. The appearance of GFAP immunoreactivity in CPTs might be related to an ependymal differentiation of the neoplastic cells, because normal ependyma and ependymomas constantly coexpress GFAP and vimentin. The simultaneous expression of three distinct intermediate filament proteins by the same neoplastic cells is an exceedingly rare phenomenon, which has never been reported by double labeling technique in neoplasms of the central nervous system. Despite the complex antigenic profile of the CPT, which includes immunoreactivity for lu-5 antigen, S-100 protein, and EMA in most of the cases, positivity for three different epithelial markers indicates that these tumors have an epithelial nature. Moreover, the immunocytochemical typing of CPT with the panel of antibodies used in the current investigation allows differentiation from other primary and metastatic central nervous system tumors.
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2438940PMC1899777W128201709What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.