Evidence map›Paper›PMID 24389122›Full record

ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2015

Early life development in a multiethnic sample and the relation to late life cognition.

Rebecca J Melrose, Paul Brewster, María J Marquine, Anna MacKay-Brandt, Bruce Reed, Sarah T Farias, Dan Mungas

Open access · bronzeAbstract read
In one paragraph

Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Diminished Returns of Higher Parental Education on Cognition for Black Adults in Middle and Later Life.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024
    Pooled it
  2. Size at birth and cognitive ability in late life: A systematic review.International journal of geriatric psychiatry · 2019
    Pooled it
  3. Variety of Enriching Early-Life Activities Linked to Late-Life Cognitive Functioning in Urban Community-Dwelling African Americans.The journals of gerontology. Series B, Psychological sciences and social sciences · 2019
    Trial
  4. Article
  5. Associations of war-related exposures and early life adversity with late-life cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Effects of early-life environment and adulthood SES on cognitive change in a multiethnic cohort.Journal of the International Neuropsychological Society : JINS · 2023
    Article
  13. Article
  14. Life-course inequalities in intrinsic capacity and healthy ageing, China.Bulletin of the World Health Organization · 2023
    Article
  15. Article
  16. APOE Effects on Late Life Cognitive Trajectories in Diverse Racial/Ethnic Groups.Journal of the International Neuropsychological Society : JINS · 2023
    Article
  17. Article
  18. Review
  19. Measuring Cognitive Health in Ethnically Diverse Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Rebecca J MelroseVA Greater Los Angeles Healthcare System, California. Department of Psychiatry & Biobehavioral Sciences at the David Geffen School of Medicine, University of California, Los Angeles. rebecca.melrose@va.gov.
Paul BrewsterDepartment of Psychology, University of Victoria, British Columbia, Canada.
María J MarquineDepartment of Psychiatry, University of California San Diego.
Anna MacKay-BrandtDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York.
Bruce ReedDepartment of Neurology, School of Medicine, University of California, Davis.
Sarah T FariasDepartment of Neurology, School of Medicine, University of California, Davis.
Dan MungasDepartment of Neurology, School of Medicine, University of California, Davis.
University of California, Davis · USColumbia University · USUniversity of California, San Diego · USUniversity of Victoria · CAVA Greater Los Angeles Healthcare System · US

Funding

Treatment of HIV- and HIV+ Patients with HPV16+ CIN2/3 Using pNGLV4a-hCRTE6E7L2 DNA vaccine administered intramuscularly via electroporationP50CA098252 · NCI · JOHNS HOPKINS UNIVERSITY · PI TZYY-CHOOU WU · 2003 to 2026
$53.5M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello · 2001 to 2026
$50.4M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
Brain pathologies, reserve and cognition in aging and dementiaR01AG031563 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Evan Fletcher, SARAH E TOMASZEWSKI-FARIAS · 2009 to 2026
$8.9M
Research Training in Late-Life NeuroPsychiatric DisordersT32MH020004 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Patrick J Brown · 1998 to 2026
$6.1M
Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)T32DA031098 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello, DAVID J MOORE · 2011 to 2026
$4.6M
Heterogeneity of Mild Cognitive Impairment(MCI)R01AG021028 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 2003 to 2014
$4.6M
ENGLISH AND SPANISH ASSESSMENT OF COGNITION IN ELDERLYR01AG010220 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI MUNGAS, DAN M. · 1992 to 2012
$4.5M
INVESTIGATOR DEVELOPMENT COREP30AG043097 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HINTON, WALTER LADSON · 2012 to 2017
$2.9M
Conference on Advanced Psychometric Methods in Cognitive Aging ResearchR13AG030995 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MUNGAS, DAN M. · 2008 to 2022
$620k
CIHRNCI NIH HHS P50 CA098252NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG043097NIA NIH HHS P30 AG10129NIA NIH HHS R01 AG010220NIA NIH HHS R01 AG021028NIA NIH HHS R01 AG10220NIA NIH HHS R01 AG AG031563NIA NIH HHS R13 AG030995NIDA NIH HHS T32 DA031098NIDA NIH HHS T32DA031098NIMH NIH HHS P30 MH062512NIMH NIH HHS T32 MH020004NIMH NIH HHS T32 MH02004
6 · The paper itself

Abstract

objectivesPoor quality of early life conditions has been associated with poorer late life cognition and increased risk of dementia. Early life physical development can be captured using adult measures of height and head circumference. Availability of resources may be reflected by socioeconomic indicators, such as parental education and family size. We sought to determine the association between early life development and experience and late life semantic memory, episodic memory, and executive functioning abilities, as well as rate of cognitive decline.

methodThis study was conducted using the UC Davis Aging Diversity cohort, an ethnically diverse sample of Caucasian, African American, and Hispanic individuals from northern California. We used latent variable modeling to measure growth and childhood socioeconomic environment (SES) and examine their associations with longitudinal cognitive outcomes using mixed effects modeling.

resultsGrowth was positively related to higher childhood SES. Higher childhood SES was associated with better semantic memory. Both low growth and low SES were associated with increased rate of cognitive decline. DISCUSSION: These findings demonstrate that early life experiences influence the trajectory of cognitive aging. Early life development and experience appears to provide a distal basis upon which additional risk and protective factors interact in the development of dementia.

Indexed as

Social ClassAgedAged, 80 and overAgingCaliforniaChildChild DevelopmentCognition DisordersExecutive FunctionHumansLife Change EventsMaleMemoryMemory, EpisodicCognitionLongitudinal changeMinority and diverse populations

Identifiers

PMID24389122
PMCPMC4462667
OpenAlexW2115367834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.