ReviewFrontiers in neuroendocrinology2014
Mouse model systems to study sex chromosome genes and behavior: relevance to humans.
Review in Frontiers in neuroendocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed.
- Sry-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: Four Core Genotypes and more.Biology of sex differences · 2026Article
- Morphological Sex Reversal in the Sexually Dimorphic Nucleus of the Preoptic Area in the Hypothalamus Delineated by Calbindin D28k-Immunoreactive Cell Clusters in YActa histochemica et cytochemica · 2025Article
- Inclusion of Sex as a Biological Variable in Biomedical Sciences at the Undergraduate Level and Beyond.Journal of women's health (2002) · 2023Article
- Sex chromosome mechanisms in cardiac development and disease.Nature cardiovascular research · 2023Article
- Gonadal hormones and sex chromosome complement differentially contribute to ethanol intake, preference, and relapse-like behaviour in four core genotypes mice.Addiction biology · 2022Article
- Strategies for Maintaining Brain Health: The Role of Stroke Risk Factors Unique to Elderly Women.Stroke · 2022Review
- Sex-limited chromosomes and non-reproductive traits.BMC biology · 2022Review
- Integrating Sex Chromosome and Endocrine Theories to Improve Teaching of Sexual Differentiation.Cold Spring Harbor perspectives in biology · 2022Article
- Differences/Disorders of Sex Development: Medical Conditions at the Intersection of Sex and Gender.Annual review of clinical psychology · 2022Review
- Sex differences in behavior, response to LPS, and glucose homeostasis in middle-aged mice.Behavioural brain research · 2022Article
- Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease.Acta pharmaceutica Sinica. B · 2022Review
- Sex, aging and immunity in multiple sclerosis and experimental autoimmune encephalomyelitis: An intriguing interaction.Frontiers in neurology · 2022Review
- Four Core Genotypes and XY* mouse models: Update on impact on SABV research.Neuroscience and biobehavioral reviews · 2020Review
- Sexual differentiation of brain and other tissues: Five questions for the next 50 years.Hormones and behavior · 2020Review
- Sex as a Biological Variable in Preclinical Modeling of Blast-Related Traumatic Brain Injury.Frontiers in neurology · 2020Review
- Genome-Wide Sex and Gender Differences in Cancer.Frontiers in oncology · 2020Review
- Sexually Dimorphic Formation of the Preoptic Area and the Bed Nucleus of the Stria Terminalis by Neuroestrogens.Frontiers in neuroscience · 2020Review
- VARIABLE PRIORITIZATION IN NONLINEAR BLACK BOX METHODS: A GENETIC ASSOCIATION CASE STUDYThe annals of applied statistics · 2019Article
- The mouse as a model of fundamental concepts related to Turner syndrome.American journal of medical genetics. Part C, Seminars in medical genetics · 2019Review
- Rethinking sex determination of non-gonadal tissues.Current topics in developmental biology · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Sex chromosome genes directly influence sex differences in behavior. The discovery of the Sry gene on the Y chromosome (Gubbay et al., 1990; Koopman et al., 1990) substantiated the sex chromosome mechanistic link to sex differences. Moreover, the pronounced connection between X chromosome gene mutations and mental illness produces a strong sex bias in these diseases. Yet, the dominant explanation for sex differences continues to be the gonadal hormones. Here we review progress made on behavioral differences in mouse models that uncouple sex chromosome complement from gonadal sex. We conclude that many social and cognitive behaviors are modified by sex chromosome complement, and discuss the implications for human research. Future directions need to include identification of the genes involved and interactions with these genes and gonadal hormones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.