Evidence map›Paper›PMID 24388848›Full record

ArticleCurrent biology : CB2014

A novel analgesic isolated from a traditional Chinese medicine.

Yan Zhang, Chaoran Wang, Lien Wang, Gregory Scott Parks, Xiuli Zhang, Zhimou Guo, Yanxiong Ke, Kang-Wu Li, Mi Kyeong Kim, Benjamin Vo and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Recent Advances in Alkaloids fromMolecules (Basel, Switzerland) · 2024
    Review
  8. Article
  9. Article
  10. Large variability in the alkaloid content ofFrontiers in pharmacology · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Frontiers in neuroscience · 2022
    Review
  17. The Analgesic Properties ofMolecules (Basel, Switzerland) · 2021
    Review
  18. The Extract ofPharmaceuticals (Basel, Switzerland) · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Yan ZhangDepartment of Pharmacology, University of California, Irvine, Irvine, CA 92697, USA.
Chaoran WangDalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Lien WangDepartment of Pharmacology, University of California, Irvine, Irvine, CA 92697, USA.
Gregory Scott ParksDepartment of Pharmacology, University of California, Irvine, Irvine, CA 92697, USA.
Xiuli ZhangDalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Zhimou GuoDalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Yanxiong KeSchool of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Kang-Wu LiDepartment of Anesthesiology and Perioperative Care, University of California, Irvine, CA 92697, USA.
Mi Kyeong KimDepartment of Anesthesiology and Perioperative Care, University of California, Irvine, CA 92697, USA.
Benjamin VoDepartment of Anesthesiology and Perioperative Care, University of California, Irvine, CA 92697, USA.
Emiliana BorrelliDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697, USA.
Guangbo GeDalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Ling YangDalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Zhiwei WangDepartment of Pharmacology, University of California, Irvine, Irvine, CA 92697, USA.
M Julia Garcia-FusterDepartment of Pharmacology, University of California, Irvine, Irvine, CA 92697, USA.
Z David LuoDepartment of Anesthesiology and Perioperative Care, University of California, Irvine, CA 92697, USA.
Xinmiao LiangDalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. Electronic address: liangxm@dicp.ac.cn.
Olivier CivelliDepartment of Pharmacology, University of California, Irvine, Irvine, CA 92697, USA; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92697, USA; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: ocivelli@uci.edu.
University of California, Irvine · USChinese Academy of Sciences · CNDalian Institute of Chemical Physics · CNEast China University of Science and Technology · CN

Funding

CHARACTERIZATION OF TWO NOVEL NEUROPEPTIDESR01MH060231 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI CIVELLI, OLIVIER · 1999 to 2008
$2.7M
A novel neuropeptide system involved in drug abuseR01DA024746 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CIVELLI, OLIVIER · 2010 to 2013
$1.5M
Hepatic Encephalopathy in Alcoholic Cirrhosis: A Systems Biology ApproachR01AA020203 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI BAJAJ, JASMOHAN S · 2010 to 2012
$1.0M
High-Throughput Assay for G-Protein Coupled Receptors in Pain ResearchR03DA026557 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CIVELLI, OLIVIER · 2008 to 2008
$25k
NIAAA NIH HHS R01 AA020203NIDA NIH HHS DA024746NIDA NIH HHS R01 DA024746NIDA NIH HHS R03 DA026557NIMH NIH HHS MH60231NIMH NIH HHS R01 MH060231
6 · The paper itself

Abstract

backgroundCurrent pain management is limited, in particular, with regard to chronic pain. In an attempt to discover novel analgesics, we combined the approach developed to characterize traditional Chinese medicine (TCM), as part of the "herbalome" project, with the reverse pharmacology approach aimed at discovering new endogenous transmitters and hormones.

resultsIn a plant used for centuries for its analgesic properties, we identify a compound, dehydrocorybulbine (DHCB), that is effective at alleviating thermally induced acute pain. We synthesize DHCB and show that it displays moderate dopamine receptor antagonist activities. By using selective pharmacological compounds and dopamine receptor knockout (KO) mice, we show that DHCB antinociceptive effect is primarily due to its interaction with D2 receptors, at least at low doses. We further show that DHCB is effective against inflammatory pain and injury-induced neuropathic pain and furthermore causes no antinociceptive tolerance.

conclusionsOur study casts DHCB as a different type of analgesic compound and as a promising lead in pain management.

Indexed as

Medicine, Chinese TraditionalAlkaloidsAnalgesicsAnimalsCorydalisHEK293 CellsHumansInflammationIsoquinolinesMaleMicePainAlkaloidsAnalgesicsdehydrocorybulbineIsoquinolines

Identifiers

PMID24388848
PMCPMC3912990
OpenAlexW2115912802

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.